首页> 外文期刊>Infection and immunity >The Small Nucleoid-Binding Proteins H-NS, HU, and Fis Affect hilA Expression in Salmonella enterica Serovar Typhimurium
【24h】

The Small Nucleoid-Binding Proteins H-NS, HU, and Fis Affect hilA Expression in Salmonella enterica Serovar Typhimurium

机译:小核仁结合蛋白H-NS,HU和Fis影响肠炎沙门氏菌鼠伤寒沙门氏菌中的hilA表达。

获取原文
           

摘要

hilA encodes an activator of Salmonella enterica serovar Typhimurium virulence genes and is transcriptionally modulated by environmental conditions. We show that H-NS represses hilA under low-osmolarity conditions. H-NS, HU, and Fis also appear to affect the derepression of hilA by HilD. Modulation of hilA by counteracting repressing and derepressing mechanisms may allow Salmonella serovar Typhimurium to regulate its virulence genes in response to different situations in vivo.
机译: hilA 编码 Salmonella enterica 鼠伤寒鼠伤寒毒力基因的激活剂,并受环境条件转录调控。我们显示H-NS在低渗透压条件下抑制 hilA 。 H-NS,HU和Fis也似乎会影响HilD对 hilA 的抑制。通过抵消抑制和去抑制机制来调控 hilA ,可能使 Salmonella 血清型鼠伤寒沙门氏菌能够响应体内的不同情况来调节其毒力基因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号