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Characterization of Cryptosporidium meleagridis of Human Origin Passaged through Different Host Species

机译:通过不同宿主物种传播的人类起源隐孢子虫的表征

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Cryptosporidium meleagridis, a protozoon first observed in turkeys, has been linked by several investigators to cryptosporidiosis in humans. C. meleagridis is the only known Cryptosporidium species that infects both avian and mammalian species. We describe the successful propagation of C. meleagridis (isolate TU1867), originally purified from a patient with diarrhea, in laboratory animals including chickens, mice, piglets, and calves. TU1867 was readily transmitted from one animal host to another, maintaining genetic homogeneity and stability. The rate of infectivity and virulence of TU1867 for the mammalian species were similar to those of Cryptosporidium parvum. Laboratory propagation of genetically and phenotypically stable and well-characterized reference isolates, representing various Cryptosporidium species, particularly those infectious to humans, will improve considerably the spectrum and quality of laboratory and field investigations on this medically important protozoa.
机译:最早在火鸡中发现的原生动物 Cryptosporidium meleagridis ,已被一些研究人员与人类隐孢子虫病联系在一起。 C。 meleagridis 是唯一已知的同时感染禽类和哺乳动物的 Cryptosporidium 物种。我们描述了 C的成功传播。 meleagridis (分离的TU1867),最初是从腹泻患者中纯化而来的,实验动物包括鸡,小鼠,仔猪和犊牛。 TU1867易于从一种动物宿主传播到另一种动物,从而保持了遗传同质性和稳定性。 TU1867对哺乳动物的感染率和毒力与隐孢子虫相似。代表各种 Cryptosporidium 物种(尤其是对人类具有感染力)的遗传和表型稳定且特征明确的参考分离株的实验室繁殖,将大大改善对该医学上重要的原生动物进行实验室和现场调查的范围和质量。

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