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首页> 外文期刊>Infection and immunity >Synergism of Gamma Interferon and Interleukin-5 in the Control of Murine Filariasis
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Synergism of Gamma Interferon and Interleukin-5 in the Control of Murine Filariasis

机译：γ干扰素和白细胞介素5在小鼠丝虫病控制中的协同作用。

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There has been a prevailing perception that Th1 and Th2 immune responses induce antagonistic immune effector mechanisms during an infection. We investigated the role of the Th1 cytokine gamma interferon (IFN-γ) and the Th2 cytokine interleukin-5 (IL-5) in murine filariasis infections with the rodent filarial nematode Litomosoides sigmodontis with regard to immune responses to the parasite. Earlier data showed an important role for IL-5 and IFN-γ in effective immune responses to filarial infection. Therefore, in this study it was asked whether IL-5 and IFN-γ act synergistically or antagonistically. Indeed, IL-5 as well as IFN-γ knockout (KO) mice show a higher worm load than the wild-type controls. IFN-γ/IL-5 double-KO mice had a significantly higher worm load than any of the single-KO mice, suggesting a synergism between IFN-γ and IL-5 in controlling worm infection. Neutrophils are known to play an important role for the containment and encapsulation process of the worms. In infected IFN-γ KO, IL-5 KO, and IFN-γ/IL-5 double-KO mice, neutrophils were significantly reduced in chemotactic activity levels compared to controls. In addition, the level of phagocytosis activity of neutrophils from IFN-γ/IL-5 double-KO mice was further decreased in comparison to that of the single-KO mice. Levels of tumor necrosis factor alpha, which is an important factor for neutrophil activation, were found to be reduced in macrophages from KO mice. In conclusion, these results argue for immune effector mechanisms in murine filarial infection that are dependent on both IFN-γ and IL-5. Synergistic effects of the two cytokines may be mediated, at least in part, by neutrophils for the control of adult worms.
机译：人们普遍认为Th1和Th2免疫反应会在感染过程中诱导拮抗的免疫效应机制。我们研究了Th1细胞因子γ干扰素（IFN-γ）和Th2细胞因子白介素5（IL-5）在鼠丝虫线虫 Litomosoides sigmodontis 的鼠丝虫病感染中的作用。去寄生虫。早期数据显示IL-5和IFN-γ在有效的丝虫感染免疫反应中起着重要作用。因此，在这项研究中，有人问IL-5和IFN-γ是协同作用还是拮抗作用。实际上，IL-5和IFN-γ敲除（KO）小鼠显示出比野生型对照更高的蠕虫负荷。 IFN-γ/ IL-5双KO小鼠的蠕虫负荷明显高于任何单KO小鼠，表明IFN-γ和IL-5在控制蠕虫感染方面具有协同作用。已知中性粒细胞在蠕虫的遏制和包封过程中起着重要作用。与对照组相比，在感染的IFN-γKO，IL-5 KO和IFN-γ/ IL-5 double-KO小鼠中，中性粒细胞的趋化活性水平显着降低。另外，与单KO小鼠相比，来自IFN-γ/ IL-5双KO小鼠的嗜中性白细胞的吞噬活性水平进一步降低。肿瘤坏死因子α（中性粒细胞激活的重要因素）的水平在KO小鼠的巨噬细胞中被发现降低。总之，这些结果证明了鼠丝虫感染的免疫效应机制既依赖于IFN-γ，又依赖于IL-5。两种细胞因子的协同作用可以至少部分地由嗜中性粒细胞介导，以控制成虫。

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