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首页> 外文期刊>Infection and immunity >CpG Oligodeoxynucleotides Improve the Survival of Pregnant and Fetal Mice following Listeria monocytogenes Infection
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CpG Oligodeoxynucleotides Improve the Survival of Pregnant and Fetal Mice following Listeria monocytogenes Infection

机译：单核细胞增生性李斯特菌感染后CpG寡脱氧核苷酸可改善孕妇和胎儿的存活率

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Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.
机译：怀孕期间李斯特菌感染可导致母亲和胎儿死亡。先前的研究表明，免疫刺激性CpG寡脱氧核苷酸（ODN）可以提高成年小鼠对许多传染性病原体（包括单核细胞增生性李斯特菌）的抵抗力。这项研究检查了CpG ODN引发的先天免疫应答是否可以降低妊娠小鼠对​​致命性利斯特氏菌攻击的敏感性。结果表明，CpG ODN处理可显着提高孕产妇生存率并减少病原体向后代的传播。怀孕期间施用的CpG ODN不会引起流产，先天缺陷或减少垫料的大小或健康。这些发现表明，CpG ODN可能提供一种安全有效的方法，以改善怀孕期间母亲和胎儿的健康。

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