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首页> 外文期刊>Infection and immunity >Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae.
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Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae.

机译：吸血和毒力是肺炎支原体的可分离特性。

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摘要

A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, no cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.
机译：选择性富集技术被用于分离肺炎支原体的血沉阴性反应突变株的血沉阳性回复株。已显示，这种血液吸附阳性还原剂可同时恢复在气管环呼吸道上皮上附着于神经氨酸酶敏感受体的能力，以及合成三种不是由血液吸附阴性产生的毒力特异性菌株蛋白的能力突变体。尽管在感染后9到12周内，逆转剂在仓鼠肺组织中持续存在，但未观察到细胞病理学。鼻内接种该回复株不能有效地抵抗强毒的肺炎支原体。

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