Clostridium tetani growth and toxin production in the intestines of germfree rats.

C L Wells; E Balish

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Clostridium tetani growth and toxin production in the intestines of germfree rats.

机译：无菌大鼠中破伤风梭菌的生长和毒素产生。

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Germfree rats were challenged orally and intrarectally with spores of Clostridium tetani. Although C. tetani spores remained viable in the intestinal tract, they were unable to germinate. Germfree rats were then challenged orally with vegetative cells of C. tetani. Vegetative cells were able to colonize the intestinal tract, replicate, and produce toxin. Tetanus antitoxin, but no tetanus toxin, was detected in the sera of monoassociated rats.

机译：用破伤风梭状芽胞杆菌的孢子口服和直肠内攻击无生殖的大鼠。尽管破伤风梭状芽胞杆菌的孢子在肠道中仍然可以存活，但它们无法发芽。然后用破伤风梭菌的营养细胞口服对无生殖力的大鼠进行攻击。营养细胞能够在肠道中定植，复制并产生毒素。在单关联大鼠的血清中未检测到破伤风抗毒素，但未检测到破伤风毒素。

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《Infection and immunity》 |1983年第2期|共3页
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C L Wells; E Balish;
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中图分类医学免疫学;
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1. Clostridium tetani growth and toxin production in the intestines of germfree rats. [J] . C L Wells, E Balish Infection and immunity . 1983,第2期

机译：无菌大鼠中破伤风梭菌的生长和毒素产生。
2. Tetanus toxin production from Clostridium tetani, using a casein-based medium in a single-use bioreactor [J] . Chung Yong-Ju, Jung Mi-Young, Lee Jin-A, Biotechnology and bioprocess engineering . 2016,第4期

机译：在一次性生物反应器中使用酪蛋白基培养基从破伤风梭菌生产破伤风毒素
3. Fed-Batch Production of Tetanus Toxin by Clostridium Tetani [J] . Fernando Fratelli, Tatiana Joly Siquini, Marcelo Estima de Abreu Biotechnology Progress . 2010,第1期

机译：破伤风梭菌补料分批生产破伤风毒素
4. CLOSTRIDIUM TETANI (C. TETANI) CULTIVATION PROCESS MONITORING BY HEADSPACE SOLIDPHASE MICROEXTRACTION (HS-SPME) COMBINED WITH GC-MS [C] . Ali Es-haghi, Masoud Ghader, Nader Shokoufi, International Mass Spectrometry Conference . 2018

机译：通过顶空固相微萃取（HS-SPME）与GC-MS相结合，卷曲蒂特坦（C.Tetani）培养过程监测
5. Development of peptide inhibitors targeting Clostridium difficile toxins A/B and characterizing the regulatory role of a putative negative regulator TcdC in Clostridium difficile toxin gene expression. [D] . Abdeen, Sanofar J. 2013

机译：靶向艰难梭菌毒素A / B的肽抑制剂的开发以及表征推定的负调节剂TcdC在艰难梭菌毒素基因表达中的调节作用。
6. Clostridium tetani growth and toxin production in the intestines of germfree rats. [O] . C L Wells, E Balish 1983

机译：无菌大鼠中破伤风梭菌的生长和毒素产生。
7. The Effect of Glutamate on Toxin Production by Clostridium tetani [O] . J. MELLANBY 1968

机译：谷氨酸对Tetani梭菌毒素生产的影响
8. Effect of Iron on Growth and Toxin Production by Clostridium botulinum Type A. [R] . Siegel, L. S. 1981

机译：铁对a型肉毒梭菌生长和毒素产生的影响

Clostridium tetani growth and toxin production in the intestines of germfree rats.

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