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首页> 外文期刊>Infection and immunity >Host defenses in murine malaria: characteristics of protracted states of immunity to Plasmodium berghei.
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Host defenses in murine malaria: characteristics of protracted states of immunity to Plasmodium berghei.

机译：鼠类疟疾中的宿主防御：对伯氏疟原虫的免疫力处于长期状态的特征。

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摘要

Vaccination of 8-week-old B6D2 (C57BL/6 x DBA/2) mice with Formalin-killed asexual erythrocytic stages of Plasmodium berghei provided a capacity to survive challenge with lethal P. berghei for more than 542 days. Although long-lived, this immunity did not provide a capacity to immediately neutralize parasites in a challenge; significant levels of erythrocytic infection occurred transiently after each challenge. The quality of long-lived immunity was not enhanced by an injection of live parasites 2 weeks after the last injection of killed antigen. The results suggest that it will be difficult to design a vaccination regimen which will provide long-lived protection from overt erythrocytic-stage infection.
机译：对8周大的B6D2（C57BL / 6 x DBA / 2）小鼠接种福尔马林杀死的无性伯氏疟原虫红细胞生成期，可使其在致命的伯氏疟原虫中存活超过542天。尽管寿命长，但这种免疫力不能提供在攻击中立即中和寄生虫的能力。每次攻击后短暂发生大量的红细胞感染。在最后一次注射杀死的抗原后2周注射活寄生虫并不能提高长寿命免疫的质量。结果表明，将难以设计一种疫苗接种方案，该疫苗接种方案可提供长期的保护，免受明显的红细胞阶段感染。

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