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首页> 外文期刊>Infection and immunity >Pathogenesis of K papovavirus infection in athymic nude mice.
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Pathogenesis of K papovavirus infection in athymic nude mice.

机译:无胸腺裸鼠中K乳头状病毒感染的发病机理。

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The fatal outcome of K virus infection in infant mice and cytoxan-treated adult mice is related to their inability to mount a prompt antibody response to the virus. Athymic nude mice infected with K virus exhibited no clinical illness and no detectable virus-specific immunoglobulin G (IgG) response, but they did exhibit a low level of virus-specific immunoglobulin M response. Transfer of spleen cells from K virus-primed nude mice to infected infant mice conferred complete protection against K virus-induced mortality. This protection was diminished by the depletion of B cells but not by the depletion of adherent cells from the primed spleen cells. B cell response is therefore important in the recovery of nude mice from K virus infection.
机译:婴儿小鼠和经细胞丹治疗的成年小鼠中K病毒感染的致命结局与它们无法对病毒引起迅速的抗体反应有关。被K病毒感染的无胸腺裸鼠没有临床疾病,也没有可检测到的病毒特异性免疫球蛋白G(IgG)反应,但是它们确实表现出低水平的病毒特异性免疫球蛋白M反应。将脾细胞从K病毒致敏的裸鼠转移至受感染的婴儿小鼠,可完全抵抗K病毒引起的死亡。 B细胞的耗竭减弱了这种保护作用,但初免的脾脏细胞的粘附细胞却没有减少这种保护作用。因此,B细胞应答在从K病毒感染中恢复裸鼠中很重要。

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