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首页> 外文期刊>Infection and immunity >Reaction of human colostral and early milk antibodies with oral streptococci.
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Reaction of human colostral and early milk antibodies with oral streptococci.

机译：人初乳和初乳抗体与口服链球菌的反应。

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Colostrum or early breast milk or both from each of 16 healthy women contained agglutinating antibodies for all normal streptococcal inhabitants of the human oral cavity (S. mutans, S. sanguis, S. mitis, and S. salivarius), including those which colonize the neonatal oral cavity in significant numbers. Agglutination correlated with the amount of immunoglobulin A (IgA) binding to bacterial surfaces as measured by mixed reverse passive antiglobulin hemagglutination. Surprisingly, colostral IgA agglutinated our control organism, Brucella abortus. Low levels of colostral or milk IgM and IgG antibodies also reacted with all of the test bacteria. Absorption studies with an enzyme-linked immunosorbent assay showed that a proportion of antibodies in colostrum and early milk is specific for each of the different oral streptococci. Fractionation on Sepharose 4B indicated that 11S secretory IgA is the predominant form of colostral and milk antibody for all of the test bacteria, including B. abortus. No evidence was found that reactions other than antigen-antibody reactions resulted in binding of colostral immunoglobulins by any of the test bacteria.
机译：16名健康女性的初乳或早期母乳或两者均含有针对人口腔中所有正常链球菌居民（变形链球菌，血红链球菌，链球菌和唾液链球菌）的凝集抗体，包括那些定植在结肠中的人。新生儿口腔中有大量。凝集与免疫球蛋白A（IgA）与细菌表面结合的数量有关，如通过混合反向被动抗球蛋白血凝测定。令人惊讶的是，初乳IgA凝集了我们的对照生物流产布鲁氏菌。低水平的初乳或牛奶中的IgM和IgG抗体也会与所有测试细菌发生反应。酶联免疫吸附试验的吸收研究表明，初乳和早乳中的抗体比例对每种不同的口服链球菌都具有特异性。在Sepharose 4B上进行分级分离表明，11S分泌型IgA是所有受试细菌（包括流产双歧杆菌）的初乳和乳抗体的主要形式。没有证据表明，除抗原-抗体反应以外的其他反应均导致任何测试细菌结合体球免疫球蛋白。

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