Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b.

J R Schreiber; C J Basker; G R Siber

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Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b.

机译：补体耗竭对抗荚膜抗体介导的b型流感嗜血杆菌实验性感染免疫的影响。

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Antibody to the capsular polysaccharide of Haemophilus influenzae type b (Hib) was not protective in infant rats depleted of complement by cobra venom factor (CoVF) even when serum antibody levels were many times the minimum protective level. Partial protection from Hib infection was achieved in CoVF-treated rats only if they were passively hyperimmunized with large doses of immunoglobulin G Hib capsular polysaccharide antibody. In addition, nonimmune CoVF-treated rats had higher mortality and blood bacterial density than nonimmune rats with intact complement systems.

机译：即使当血清抗体水平是最低保护水平的许多倍时，b型流感嗜血杆菌荚膜多糖（Hib）抗体对补充了眼镜蛇毒因子（CoVFF）补体的幼鼠也没有保护作用。仅在CoVF治疗的大鼠中接受大剂量的免疫球蛋白G Hib荚膜多糖抗体被动超免疫后，才能部分保护其免受Hib感染。另外，与具有完整补体系统的非免疫大鼠相比，非免疫CoVF治疗的大鼠具有更高的死亡率和血液细菌密度。

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《Infection and immunity》 |1987年第11期|共4页
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J R Schreiber; C J Basker; G R Siber;
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中图分类医学免疫学;
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1. Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b. [J] . J R Schreiber, V A Barrus, G R Siber Infection and immunity . 1985,第1期

机译：降低的和烷基化的人类免疫血清球蛋白在b型流感嗜血杆菌实验感染中的防护作用降低。
2. Activation of the alternative complement pathway by Haemophilus influenzae type B. [J] . P H Quinn, F J Crosson, J A Winkelstein, Infection and immunity . 1977,第1期

机译：B型流感嗜血杆菌激活替代补体途径。
3. Intensive treatment for childhood acute lymphoblastic leukemia reduces immune responses to diphtheria, tetanus, and Haemophilus influenzae type b. [J] . Ek T, Mellander L, Hahn Zoric M, Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2004,第11期

机译：儿童期急性淋巴细胞白血病的强化治疗会降低对b型白喉，破伤风和流感嗜血杆菌的免疫反应。
4. Investigations into treatment strategies aiding the immune response to Haemophilus Influenzae [C] . Rundell, A., DeCarlo, . 1997

机译：有助于对流感嗜血杆菌免疫应答的治疗策略的研究
5. Sialic Acid-mediated Protection of Nontypeable Haemophilus influenzae from Immune Defenses Targeting Cell Surface Glycans [D] . Jackson, Mary Darby. 2020

机译：唾液酸介导的免疫防御靶向细胞表面聚糖免疫防御的保护保护
6. Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b. [O] . J R Schreiber, C J Basker, G R Siber 1987

机译：补体耗竭对抗荚膜抗体介导的b型流感嗜血杆菌实验性感染免疫的影响。
7. Role of complement in mouse macrophage binding of Haemophilus influenzae type b. [O] . Noel, G J, Mosser, D M, Edelson, P J 1990

机译：补体在b型流感嗜血杆菌的小鼠巨噬细胞结合中的作用。

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Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b.

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