Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns.

H Bousseboua; Y Le Coz; J Dabard; O Szylit; P Raibaud; M R Popoff; P Ravisse

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Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns.

机译：与分离自新生儿坏死性小肠结肠炎患者和健康新生儿的酪酸梭状芽孢杆菌菌株单联的gnotobiotic鹌鹑的实验性盲肠炎。

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Using axenic quails fed a diet containing lactose, we have investigated the potentially pathogenic roles of six Clostridium butyricum strains of human origin. Three strains (CB155-3, CB1002, and CB203-1) isolated from neonatal necrotizing enterocolitis patients and two of three strains (CB19-1 and CB25-2) isolated from healthy newborns led to cecal or crop lesions or both similar to those observed in human neonatal necrotizing enterocolitis: thickening of the cecal wall with gas cysts, hemorrhagic ulcerations, and necrotic areas. The lactose-negative strain (CB46-1) did not develop any lesions. The neuraminidase-producing strain (CB155-3) caused lesions in all monoassociated quails, whereas the other strains caused lesions in 28 to 85% of animals. Removal of dietary lactose suppressed all pathological incidence. These results show that lactose fermentation is a prerequisite in these pathological changes and stress the roles played by both the strain and the host in the expression of C. butyricum enteropathogenicity.

机译：我们使用饲喂含乳糖饮食的轴突鹌鹑，研究了六种人类起源的丁酸梭菌菌株的潜在致病作用。从新生儿坏死性小肠结肠炎患者中分离出的三株（CB155-3，CB1002和CB203-1）和从健康新生儿中分离出的三株（CB19-1和CB25-2）中的两株导致盲肠或农作物病变或两者均与观察到的相似在人类新生儿坏死性小肠结肠炎中：盲肠壁增厚，囊肿，出血性溃疡和坏死区域。乳糖阴性菌株（CB46-1）未出现任何病变。产生神经氨酸酶的菌株（CB155-3）引起所有单关联鹌鹑的损伤，而其他菌株引起28％至85％的动物损伤。去除饮食中的乳糖可抑制所有病理发生。这些结果表明，乳糖发酵是这些病理变化的先决条件，并强调了菌株和宿主在丁酸梭菌肠致病性表达中所起的作用。

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《Infection and immunity》 |1989年第3期|共5页
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H Bousseboua; Y Le Coz; J Dabard; O Szylit; P Raibaud; M R Popoff; P Ravisse;
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1. Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns. [J] . H Bousseboua, Y Le Coz, J Dabard, Infection and immunity . 1989,第3期

机译：与分离自新生儿坏死性小肠结肠炎患者和健康新生儿的酪酸梭状芽孢杆菌菌株单联的gnotobiotic鹌鹑的实验性盲肠炎。
2. Experimental cecitis in gnotoxenic chickens monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis. [J] . M R Popoff, O Szylit, P Ravisse, Infection and immunity . 1985,第3期

机译：与新生坏死性小肠结肠炎患者分离的丁酸梭状芽孢杆菌菌株单联的地精制鸡的实验性盲肠炎。
3. Multidisciplinary evaluation of Clostridium butyricum clonality isolated from preterm neonates with necrotizing enterocolitis in South France between 2009 and 2017 [J] . Michel Hosny, Jacques Yaacoub Bou Khalil, Aurelia Caputo, Scientific reports. . 2019,第1期

机译：2009年至2017年间在法国南部从早产儿坏死性小肠结肠炎中分离出来的丁酸梭菌克隆性的多学科评估
4. Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns. [O] . H Bousseboua, Y Le Coz, J Dabard, 1989

机译：与分离自新生儿坏死性小肠结肠炎患者和健康新生儿的酪酸梭状芽孢杆菌菌株相关的生食性鹌鹑实验性盲肠炎。
5. Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns [O] . H Bousseboua, Y Le Coz, J Dabard, 1989

机译：用患有新生儿坏死性小肠结肠炎和健康新生儿的患者分离的牛肝菌鹌鹑中的实验性咽喉单独分离。

Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns.

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