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首页> 外文期刊>Infection and immunity >Helicobacter felis gastritis in gnotobiotic rats: an animal model of Helicobacter pylori gastritis.
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Helicobacter felis gastritis in gnotobiotic rats: an animal model of Helicobacter pylori gastritis.

机译：gnotobiotic大鼠中的猫幽门螺杆菌胃炎：幽门螺杆菌胃炎的动物模型。

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The gastric spirillum Helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. Studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with H. felis. At 2 weeks postinoculation, the gastric mucosa of germfree rats had lymphocytes and eosinophils scattered in small foci throughout the subglandular region of the antrum. Small numbers of lymphocytes were present in the subglandular portion of the antral mucosa that focally extended through the lamina propria towards the luminal surface. Eight weeks postinoculation, the inflammation was confined to the antrum. It was characterized by increased numbers of lymphocytes and eosinophils in the subglandular areas, with focal aggregates of lymphocytes in the submucosa. Some lymphoid aggregates extended from the submucosa through the muscularis mucosa and lamina propria to the luminal surface. H. felis was demonstrated with the Warthin-Starry stain, bacterial culture, and urease assay, particularly in the antrum. H. felis also produced a significant immunoglobulin G antibody titer at 2, 4, and 8 weeks postinoculation as well as a transitory immunoglobulin M response at 2 to 4 weeks postinoculation. Contact control rats were not infected, inferring that fecal-oral spread of H. felis did not occur.
机译：最初从猫的胃中分离出来的胃螺旋菌Helicobacter felis，定居在无菌大鼠的胃中。设计研究以检查口服H. felis的无菌大鼠的病理和血清学反应。接种后2周，无菌大鼠的胃粘膜在整个胃窦下腺区域的小灶中散布着淋巴细胞和嗜酸性粒细胞。少量的淋巴细胞存在于肛门粘膜的腺下部分，该部分聚焦地通过固有层向腔表面延伸。接种后八周，炎症仅限于胃窦。其特点是腺下区域的淋巴细胞和嗜酸性粒细胞增多，粘膜下层的淋巴细胞聚集。一些淋巴样聚集物从粘膜下层穿过肌层粘膜和固有层延伸到腔表面。用沃辛星染色，细菌培养和脲酶测定法证明了H. felis，特别是在胃窦中。在接种后2、4和8周，H。felis还产生了显着的免疫球蛋白G抗体滴度，并且在接种后2至4周产生了短暂的免疫球蛋白M反应。接触对照大鼠未受到感染，这表明未发生粪便链球菌的粪口传播。

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