• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Effect of vaccination of hens with an avirulent strain of Salmonella typhimurium on immunity of progeny challenged with wild-Type Salmonella strains.
【24h】

Effect of vaccination of hens with an avirulent strain of Salmonella typhimurium on immunity of progeny challenged with wild-Type Salmonella strains.

机译：用鼠伤寒沙门氏菌无毒株接种母鸡对野生型沙门氏菌菌株攻击的子代免疫力的影响。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The avirulent Salmonella typhimurium chi3985 was used to vaccinate white leghorn chickens at 16 and 18 weeks of age, and the effect of maternal antibody on Salmonella colonization of progeny of vaccinated hens was assessed with S. typhimurium F98 or chi3985. Progeny of hens that had been vaccinated at 1 and 3 or 2 and 4 weeks of age with chi3985 were used to determine the effect of maternal immunity on vaccine efficacy. Vaccination of hens induced long-lasting Salmonella-specific antibodies which were transferred into eggs and were detected as immunoglobulin G (IgG) in the egg yolk. Maternal antibody was detected in the progeny of vaccinated birds as IgG and IgA in serum and intestinal fluid, respectively. The titer of maternally transmitted IgG or IgA was highest in the first week of life of the progeny and declined with age. Maternal antibodies prevented colonization of the chicks by S. typhimurium chi3985 and reduced colonization by S. typhimurium F98. Overall, chicks from vaccinated hens had significantly higher antibody responses than did the progeny of nonvaccinated hens after oral infection with Salmonella strains. Maternal antibody reduced the efficacy of vaccination of progeny with chi3985 at 1 and 3 weeks of age. But vaccination at 2 and 4 weeks of age induced excellent protection against challenge with S. typhimurium F98 or S. enteritidis 27A PT 8 in birds from vaccinated hens and in specific-pathogen-free chickens. Vaccination of chickens at 2 and 4 weeks of age has been shown to protect the birds against challenge with homologous and heterologous Salmonella serotypes. A combination of vaccination of adult animals and use of the progeny of vaccinated birds will enhance effective control of Salmonella infections in the poultry industry. This will complement the present control of Salmonella-associated food poisoning caused by Salmonella enteritidis in eggs because the avirulent S. typhimurium vaccine strain chi3985 induced excellent protection against S. enteritidis in chickens.
机译：用无毒的鼠伤寒沙门氏菌chi3985接种16和18周龄的白色来亨鸡，并用鼠伤寒沙门氏菌F98或chi3985评估母源抗体对疫苗接种母鸡后代沙门氏菌定植的影响。已在1、3、2和4周龄时用chi3985疫苗接种的母鸡后代用于确定母体免疫对疫苗效力的影响。母鸡接种疫苗后会产生持久的沙门氏菌特异性抗体，这些抗体已转移到鸡蛋中，并在蛋黄中被检测为免疫球蛋白G（IgG）。在接种疫苗的鸟类的子代中检测到母体抗体，分别为血清和肠液中的IgG和IgA。母体传播的IgG或IgA的滴度在后代生命的第一周最高，并随年龄下降。母源抗体阻止了鼠伤寒沙门氏菌chi3985对小鸡的定殖，并减少了鼠伤寒沙门氏菌F98的定殖。总体而言，接种沙门氏菌菌株后，接种过母鸡的小鸡的抗体应答明显高于未接种过母鸡的后代。母体抗体降低了在1周和3周龄时用chi3985接种后代的功效。但是，在接种的母鸡和无特定病原体的鸡中，在2周和4周龄时接种疫苗可对鼠伤寒沙门氏菌F98或肠炎沙门氏菌27A PT 8产生极好的保护作用。研究表明，在2和4周龄时对鸡进行疫苗接种可以保护禽类免受沙门氏菌同源和异源血清型的攻击。成年动物疫苗接种和禽类后代疫苗的使用相结合，将提高家禽业中沙门氏菌感染的有效控制。这将补充目前对鸡蛋中肠炎沙门氏菌引起的沙门氏菌相关食物中毒的控制，因为无毒的鼠伤寒沙门氏菌疫苗菌株chi3985对鸡的肠炎沙门氏菌具有出色的保护作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号