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首页> 外文期刊>Infection and immunity >Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion.
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Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion.

机译：嗜肺军团菌与卡氏棘阿米巴菌的相互作用：通过盘绕吞噬作用吸收并抑制吞噬体-溶酶体融合。

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摘要

Legionella pneumophila is a facultative intracellular parasite able to survive within both human monocytes and amoebae. We have demonstrated that processing of L. pneumophila by the free-living amoeba Acanthamoeba castellanii shows many similarities to the processing of L. pneumophila by monocytes. These similarities include uptake of L. pneumophila by coiling phagocytosis and the subsequent confinement of L. pneumophila in a ribosome-studded phagosome. In addition, as in monocytes, inhibition of lysosomal fusion with phagosomes containing L. pneumophila was detected in amoebae. With all clinical isolates, inhibition of phagosomes-lysosome fusion correlated with virulence. However, with one of the environmental isolates tested, no significant difference in phagosome-lysosome fusion was observed between the virulent and avirulent forms. These results indicate that the avirulent form of this isolate differed from the virulent form in some other respect critical to intracellular survival. Therefore, intracellular multiplication of L. pneumophila within A. castellanii may not be solely dependent upon the inhibition of lysosomal fusion.
机译：嗜肺军团杆菌是一种兼性的细胞内寄生虫，能够在人单核细胞和变形虫中生存。我们已经证明，通过自由生活的变形虫对棘孢杆菌的处理显示了与单核细胞对付肺炎球菌的许多相似之处。这些相似之处包括通过盘绕吞噬作用摄取嗜肺乳杆菌，以及随后将嗜肺乳杆菌限制在核糖体充斥的吞噬体中。另外，在单核细胞中，在变形虫中检测到溶酶体融合物与含有嗜肺乳杆菌的吞噬体的抑制作用。对于所有临床分离株，吞噬体-溶酶体融合的抑制与毒力相关。但是，用一种环境分离株进行测试，在强毒和无毒形式之间吞噬体-溶酶体融合没有观察到显着差异。这些结果表明该分离物的无毒形式在对细胞内存活至关重要的其他方面不同于有毒形式。因此，肺炎链球菌在castellanii内的细胞内增殖可能不仅仅取决于溶酶体融合的抑制。

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