Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages.

S C Straley; P A Harmon

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Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages.

机译：鼠疫耶尔森氏菌在小鼠腹膜巨噬细胞的吞噬体中生长。

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Transmission electron microscopy was used to determine the intracellular localization of Yersinia pestis growing within cultured resident peritoneal macrophages of mice. Monolayers fixed immediately, or as long as 4.5 h, after infection contained yersiniae closely surrounded by a membrane. The vesicles containing the yersiniae were determined to be phagolysosomes by labeling secondary lysosomes of macrophages with electron-dense particles of thorium dioxide. The presence of the label within vesicles containing yersiniae indicates that this pathogen grows within the lysosomal compartment of its target host cell.

机译：使用透射电子显微镜确定在培养的小鼠腹膜巨噬细胞内生长的鼠疫耶尔森菌的细胞内定位。感染后立即或长达4.5小时固定的单层细胞含有被膜紧紧包裹的耶尔森菌。通过用电子致密二氧化or标记巨噬细胞的次级溶酶体，可以确定含有耶尔森菌的囊泡是吞噬体。含有耶尔森氏菌的囊泡中标记物的存在表明该病原体在其靶宿主细胞的溶酶体区室中生长。

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《Infection and immunity》 |1984年第3期|共5页
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S C Straley; P A Harmon;
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中图分类医学免疫学;
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1. Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages. [J] . Justin L Spinner, Seth Winfree, Tregei Starr, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2014,第3期

机译：鼠疫耶尔森氏菌在人嗜中性粒细胞吞噬体中存活和复制，巨噬细胞吸收被感染的嗜中性粒细胞。
2. Survival and growth of Yersinia pestis within macrophages and an effect of the loss of the 47-megadalton plasmid on growth in macrophages. [J] . W T Charnetzky, W W Shuford Infection and immunity . 1985,第1期

机译：鼠疫耶尔森氏菌在巨噬细胞中的存活和生长以及47兆道尔顿质粒的丢失对巨噬细胞生长的影响。
3. Growth in mouse peritoneal macrophages of Yersinia pestis lacking established virulence determinants. [J] . S C Straley, P A Harmon Infection and immunity . 1984,第3期

机译：鼠疫耶尔森氏菌的小鼠腹膜巨噬细胞的生长缺乏确定的毒力决定因素。
4. Yersinia pestis and Yersinia pseudotuberculosis diversity in the former Soviet Union and Mongolia [C] . Andrey P. Anisimov International symposium on bacterial genomics, evolution and pathogenesis. . 2010

机译：前苏联和蒙古的鼠疫耶尔森菌和假结核耶尔森菌多样性
5. Identification and characterization of genes involved in survival and replication of Yersinia pestis and Yersinia pseudotuberculosis in macrophages. [D] . Grabenstein, Jens Philip. 2005

机译：鉴定和鉴定涉及鼠疫耶尔森氏菌和假结核耶尔森氏菌在巨噬细胞中存活和复制的基因。
6. Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages. [O] . S C Straley, P A Harmon 1984

机译：鼠疫耶尔森氏菌在小鼠腹膜巨噬细胞的吞噬体中生长。
7. Phagolysosome Formation, Cyclic Adenosine 3':5'-Monophosphate and the Fate of Salmonella typhimurium within Mouse Peritoneal Macrophages [O] . M. E. W. Carrol, P. S. Jackett, V. R. Aber, 1979

机译：植物组织形成，环腺苷3'：5'-单磷酸盐和沙门氏菌血硫尿的命运在小鼠腹膜巨噬细胞内
8. Intracellular Replication of Leishmania tropica in Mouse Peritoneal Macrophages: Amastigote Infection of Resident Cells and Inflammatory Exudate Macrophages. [R] . Fortier, A. H., Hoover, D. L., Nacy, C. A. 1982

机译：小鼠腹腔巨噬细胞中利什曼原虫的细胞内复制：驻留细胞和炎性渗出物巨噬细胞的无鞭毛体感染。

Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages.

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