• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Experimental infection of pig-tailed macaques (Macaca nemestrina) with Campylobacter cinaedi and Campylobacter fennelliae.
【24h】

Experimental infection of pig-tailed macaques (Macaca nemestrina) with Campylobacter cinaedi and Campylobacter fennelliae.

机译：猪弯曲猕猴和弯曲弯曲杆菌对猪尾猕猴（Macaca nemestrina）的实验性感染。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Campylobacter cinaedi and C. fennelliae have been associated with proctocolitis, bacteremia, and asymptomatic rectal infection, primarily in homosexual men. To more directly assess the pathogenic role of these organisms, we studied their disease-producing potential in 12- to 25-day-old pig-tailed macaques (Macaca nemestrina). Four infant monkeys were challenged with 10(8) to 10(9) C. cinaedi, three were challenged with C. fennelliae, two were challenged with C. jejuni, and one received no microorganisms. Watery or loose stools without associated fever or fecal leukocytes developed 3 to 7 days postinoculation in all of the animals given C. cinaedi, C. fennelliae, and C. jejuni, but not in the control animal. Stool cultures were simultaneously positive and remained so in the animals challenged with C. cinaedi or C. fennelliae for 3 weeks after inoculation despite the resolution of clinical illness. All of the animals challenged with C. cinaedi and C. fennelliae became bacteremic, and three had clinical evidence of septicemia. Histopathologic evaluation of rectal biopsies (five animals) and necropsy (one animal) showed no evidence of mucosal disruption. Specific immunoglobulin M and immunoglobulin G antibody responses occurred in all of the animals challenged with C. cinaedi and C. fennelliae, as determined by enzyme-linked immunosorbent assay and immunoblotting. We conclude that C. cinaedi and C. fennelliae consistently produce a diarrheal illness accompanied by bacteremia and followed by prolonged gastrointestinal colonization in M. nemestrina.
机译：弯曲杆菌弯曲杆菌和茴香杆菌已与原发性结肠炎，菌血症和无症状直肠感染相关，主要在同性恋男性中。为了更直接地评估这些生物的致病作用，我们研究了它们在12至25天大的猪尾猕猴（Macaca nemestrina）中产生疾病的潜力。用10（8）到10（9）的C. cinaedi攻击四只小猴子，用茴香C. fennelliae攻击三只，用空肠弯曲杆菌（C. jejuni）攻击两只，没有一只接受微生物。接种C. cinaedi，C。fennelliae和C. jejuni的所有动物，接种后3至7天会出现水样或稀疏的大便，没有相关的发烧或粪便白细胞，但对照动物却没有。粪便培养物同时呈阳性，即使在临床症状消失的情况下，接种后仍能在3个月内受到Cinaedi或C. fennelliae攻击的动物仍保持阳性。用C. cinaedi和C. fennelliae攻击的所有动物都具有细菌性，其中三只具有败血症的临床证据。直肠活检（5只动物）和尸检（1只动物）的组织病理学评估未显示粘膜破坏的证据。如通过酶联免疫吸附测定和免疫印迹所确定的，在所有被C. cinaedi和C. fennelliae攻击的动物中，发生了特异性免疫球蛋白M和免疫球蛋白G抗体应答。我们得出的结论是C. cinaedi和C. fennelliae持续产生腹泻病，并伴有菌血症，随后在nemestrina中胃肠道定植时间延长。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号