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首页> 外文期刊>Infection and immunity >Role of beta interferon in resistance to Toxoplasma gondii infection.
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Role of beta interferon in resistance to Toxoplasma gondii infection.

机译：β干扰素在抗弓形虫感染中的作用。

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摘要

The role of recombinant murine beta interferon (rMuIFN-beta) and recombinant human IFN-beta (rHuIFN-beta) in resistance to Toxoplasma gondii was examined. rMuIFN-beta protected mice against a lethal infection with the parasite. The protective effect appeared to depend on the concomitant release of gamma interferon. rMuIFN-beta did not activate murine peritoneal macrophages to inhibit or kill T. gondii whether used alone or in combination with lipopolysaccharide (LPS). rHuIFN-beta did not activate human monocyte-derived macrophages to inhibit or kill T. gondii when 5-day-old monocyte-derived macrophages were used. In contrast, significant killing of T. gondii was noted when 10-day-old monocyte-derived macrophages were used. The addition of LPS enhanced this effect. These results revealed a role for IFN-beta in the mechanisms of defense against T. gondii and suggest its potential use in the treatment of toxoplasmosis in humans.
机译：检查了重组鼠β干扰素（rMuIFN-β）和重组人IFN-β（rHuIFN-β）在弓形虫抗性中的作用。 rMuIFN-beta保护小鼠免受寄生虫的致命感染。保护作用似乎取决于γ干扰素的伴随释放。无论单独使用还是与脂多糖（LPS）组合使用，rMuIFN-β均不激活鼠腹膜巨噬细胞来抑制或杀死弓形虫。当使用5天大的单核细胞衍生巨噬细胞时，rHuIFN-β不会激活人单核细胞衍生巨噬细胞来抑制或杀死弓形虫。相反，当使用10日龄的单核细胞衍生的巨噬细胞时，发现了弓形虫的明显杀伤。 LPS的添加增强了这种效果。这些结果揭示了IFN-β在针对弓形虫的防御机制中的作用，并暗示了其在人类弓形虫病治疗中的潜在用途。

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