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首页> 外文期刊>Infection and immunity >Serum antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-protein conjugates.
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Serum antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-protein conjugates.

机译：注射了b型流感嗜血杆菌和6A型肺炎球菌荚膜多糖-蛋白质偶联物的幼年和婴儿恒河猴的血清抗体反应。

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Juvenile and infant rhesus monkeys were injected subcutaneously with saline solutions of Haemophilus influenzae type b (Hib) and pneumococcus type 6A (Pn6A) capsular polysaccharides conjugated to either tetanus toxoid (TT), horseshoe crab hemocyanin, or cholera toxin (CT), and the antibody responses of the monkeys to both bacterial components were measured. All three Hib conjugates were immunogenic and elicited booster responses; their comparative immunogenicity was Hib-CT greater than Hib-TT greater than Hib-horseshoe crab hemocyanin. Hib alone did not elicit antibodies in the juveniles. Juveniles responded earlier and with higher levels of antibodies than did infants. TT, as well as diphtheria-tetanus toxoids-pertussis vaccine adsorbed injected concurrently at a separate site, increased both Hib and TT antibody responses in juveniles (P less than 0.05). Concurrent injection of 5 Lf of fluid TT with a nonimmunogenic 5-micrograms dose in infants elicited levels of Hib antibodies comparable to those elicited by 50 micrograms of Hib-TT. Hib antibodies elicited by the conjugates remained at protective levels in both juveniles and infants 2 months after the last injection, were bactericidal, and conferred passive immunity against bacteremia in infant rats. Passive immunization of juveniles with tetanus immune globulin before each injection of Hib-TT did not suppress Hib antibodies. Hib-TT and Hib-CT elicited increases of Hib antibodies of the immunoglobulin M and G isotypes in the infants. The Pn6A-TT conjugate was considerably less immunogenic than the Hib-TT conjugate; only a few of the juveniles or infants responded with protective levels of Pn6A antibodies. Pn6A antibodies from responders conferred protection in mice against intraperitoneal challenge with Pn6A organisms. TT antibodies were elicited in both juvenile and infant animals after one injection of 50 micrograms of Hib-TT and in the infants injected with 5 micrograms of Hib-TT plus 5 Lf of TT; 5 micrograms of Hib-TT and Pn6A-TT in combination alone did not elicit TT antibodies. Hib-CT elicited CT antibodies in both juveniles and infants.
机译：向幼年和婴儿恒河猴皮下注射b型流感嗜血杆菌（Hib）和6A型肺炎球菌（Pn6A）荚膜多糖与破伤风类毒素（TT），马蹄血蓝蛋白或霍乱毒素（CT）结合的盐溶液测量了猴子对两种细菌成分的抗体应答。所有三种Hib偶联物均具有免疫原性并引起加强反应;它们的相对免疫原性大于Hib-CT大于Hib-TT且大于Hib- crab血红蛋白。单独的Hib不会在青少年中引发抗体。与婴儿相比，青少年的反应更早，抗体水平更高。 TT以及在不同部位同时注射的吸附的白喉-破伤风类毒素-百日咳疫苗可提高青少年的Hib和TT抗体反应（P小于0.05）。在婴儿中同时注射5 Lf的非免疫原性5毫克液体TT引起的Hib抗体水平与50毫克Hib-TT引起的水平相当。在最后一次注射后2个月，结合物引起的Hib抗体在青少年和婴儿中均保持在保护水平，具有杀菌作用，并赋予婴儿大鼠抗菌血症的被动免疫力。每次注射Hib-TT之前，用破伤风免疫球蛋白对青少年进行被动免疫不会抑制Hib抗体。 Hib-TT和Hib-CT引起婴儿免疫球蛋白M和G同种型的Hib抗体增加。 Pn6A-TT偶联物的免疫原性比Hib-TT偶联物低。只有少数青少年或婴儿对Pn6A抗体的保护水平有所反应。来自应答者的Pn6A抗体可在小鼠中针对Pn6A生物腹膜内攻击提供保护。一次注射50毫克Hib-TT和注射5毫克Hib-TT加5 Lf TT的婴儿后，在幼小动物和婴儿中均诱发TT抗体;单独组合使用5毫克的Hib-TT和Pn6A-TT不会引发TT抗体。 Hib-CT在少年和婴儿中均引发CT抗体。

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