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首页> 外文期刊>Infection and immunity >Effects of ovarian hormones on manifestation of purulent endometritis in rat uteruses infected with Escherichia coli.
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Effects of ovarian hormones on manifestation of purulent endometritis in rat uteruses infected with Escherichia coli.

机译：卵巢激素对感染大肠杆菌的大鼠子宫化脓性子宫内膜炎表现的影响。

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摘要

To assess the influence of hormones on uterine infections, Escherichia coli was infused into uterine lumens of ovariectomized or adrenoovariectomized rats receiving exogenous administration of various doses of ovarian hormones. Large numbers of E. coli were recovered from the rat uterine lumens, irrespective of hormonal influences. The number of leukocytes in the uterine flushings, representing the magnitude of purulent inflammation, differed significantly depending upon the hormonal regimen given to each host. Purulent endometritis was induced by E. coli in ovariectomized rats receiving progesterone or corn oil (hormone vehicle). Infections were asymptomatic in rats receiving estradiol, but promethazine-treated uterine horns were susceptible to infection. When progesterone was administered along with estradiol, purulent inflammation was caused by E. coli, but the number of leukocytes in the uterine lumens was significantly less than that obtained from the rats treated with progesterone or corn oil. These effects of ovarian hormones on uterine infections were observed in adrenoovariectomized rats as well as in ovariectomized rats. It is suggested that estradiol alters the nature of endometrial epithelium and prevent manifestation of purulent endometritis; progesterone antagonizes estradiol. Adrenal hormones appear not to participate in the pathogenesis of endometritis induced by E. coli.
机译：为了评估激素对子宫感染的影响，将大肠埃希氏菌注入到接受外源各种剂量卵巢激素的去卵巢或肾上腺切除的大鼠的子宫腔中。不论荷尔蒙的影响，从大鼠子宫腔中回收了大量的大肠杆菌。子宫潮红中白细胞的数量，代表化脓性炎症的程度，明显不同，这取决于给予每个宿主的激素方案。大肠杆菌在接受孕酮或玉米油（激素赋形剂）的卵巢切除大鼠中由大肠杆菌诱导化脓性子宫内膜炎。接受雌二醇的大鼠无感染，但异丙嗪治疗的子宫角很容易感染。当将孕酮与雌二醇一起给药时，大肠杆菌引起化脓性炎症，但子宫腔内白细胞的数量明显少于用孕酮或玉米油治疗的大鼠。在肾上腺切除的大鼠和卵巢切除的大鼠中观察到了卵巢激素对子宫感染的这些作用。提示雌二醇可改变子宫内膜上皮的性质并预防化脓性子宫内膜炎的表现。孕酮拮抗雌二醇。肾上腺激素似乎不参与大肠杆菌诱导的子宫内膜炎的发病机制。

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