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首页> 外文期刊>Infection and immunity >Variation in expression of antibody-dependent cell-mediated cytotoxicity in rodents with malaria.
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Variation in expression of antibody-dependent cell-mediated cytotoxicity in rodents with malaria.

机译：疟疾啮齿动物中抗体依赖性细胞介导的细胞毒性表达的变化。

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摘要

Antibody-dependent cell-mediated cytotoxicity (ADCC) against mouse erythrocytes sensitized with immunoglobulin G was studied in mice with malaria. Spleen cells from mice had enhanced cytotoxic activity early in Plasmodium berghei infection but not later in the disease. Sera from infected animals and partially purified malarial immune complexes inhibited ADCC. In addition, ADCC was diminished in spleen cells from mice infected with the lethal variant of P. yoelii 17x compared with that in mice infected with the nonlethal variant. P. berghei-infected erythrocytes did not release 51Cr when incubated with effector cells unless the erythrocytes were sensitized with antibodies against normal mouse erythrocytes.
机译：在患有疟疾的小鼠中研究了针对免疫球蛋白G致敏的小鼠红细胞的抗体依赖性细胞介导的细胞毒性（ADCC）。来自小鼠的脾细胞在伯氏疟原虫感染早期具有增强的细胞毒性活性，但在疾病晚期没有增强。来自被感染动物的血清和部分纯化的疟疾免疫复合物可抑制ADCC。另外，与感染了非致死性变体的小鼠相比，感染了约氏疟原虫17x致死性变体的小鼠的脾细胞中的ADCC减少了。与效应细胞一起孵育时，感染伯氏疟原虫的红细胞不会释放51Cr，除非该红细胞被针对正常小鼠红细胞的抗体敏化。

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