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首页> 外文期刊>Infection and immunity >Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum.
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Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum.

机译：人类针对恶性疟原虫主要表面蛋白（gp190）的免疫反应的发展。

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The 190-kilodalton glycoprotein (gp190) of Plasmodium falciparum, the precursor of the major surface proteins of merozoites, is considered a promising candidate for a blood stage malaria vaccine. DNA sequences specific for the gp190 of the two isolates K1 and MAD20 were subcloned and expressed in Escherichia coli. The panel of fusion proteins obtained represents about 80% of the polymorphic sequences observed so far within various isolates of P. falciparum. Sera from individuals living in a malaria-endemic area of West Africa were tested in immunoblots against the gp190 fusion proteins, and antibody reactivity was mapped to defined regions of the gp190. Depending on the age of the individual and on the presence of parasites in the blood, distinct regions of gp190 were differentially recognized by the respective antibodies. Similarly, the analysis of sera from German patients with acute malaria revealed a distinct pattern. When grouped according to age and to parasitemia, the reactivity of the sera of people living in malaria-endemic areas may indicate a correlation between certain gp190 regions and protective immune response.
机译：恶性疟原虫的190公斤级糖蛋白（gp190）是裂殖子主要表面蛋白的前体，被认为是血液疟疾疫苗的有希望的候选者。对两个分离株K1和MAD20的gp190特异的DNA序列被亚克隆并在大肠杆菌中表达。迄今为止，在恶性疟原虫的各种分离物中观察到的融合蛋白代表约80％的多态性序列。在针对gp190融合蛋白的免疫印迹中测试了生活在西非疟疾流行地区的个体的血清，并将抗体反应性定位在gp190的指定区域。根据个体的年龄和血液中寄生虫的存在，gp190的不同区域会分别被相应的抗体识别。同样，对德国急性疟疾患者血清的分析显示出独特的模式。如果按年龄和寄生虫病分组，生活在疟疾流行地区的人的血清反应性可能表明某些gp190地区与保护性免疫反应之间存在相关性。

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