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首页> 外文期刊>Infection and immunity >Phenolic glycolipids of Mycobacterium bovis: new structures and synthesis of a corresponding seroreactive neoglycoprotein.
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Phenolic glycolipids of Mycobacterium bovis: new structures and synthesis of a corresponding seroreactive neoglycoprotein.

机译：牛分枝杆菌的酚类糖脂：相应血清反应性新糖蛋白的新结构和合成。

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摘要

The glycolipid that characterizes the majority of isolates of Mycobacterium bovis and that has come to be known as M. bovis-identifying lipid is the phenolic glycolipid mycoside B described in the literature by others. However, when mycoside B obtained from M. bovis BCG, field isolates, and infected tissues was examined in detail, it was shown to be different from that described in the literature in some important respects. In particular, the glycosyl substituent is 2-O-methyl-alpha-L-rhamnopyranose rather than 2-O-methyl-beta-D-rhamnopyranose. With this information, a seroreactive neoglycoprotein (neoantigen) containing the 2-O-methyl-alpha-L-rhamnopyranosyl substituent suitable for the serodiagnosis of bovine tuberculosis was synthesized. M. bovis also contains other minor seroreactive phenolic glycolipids, one of which is a deacylated form of mycoside B and another of which contains an alpha-L-rhamnopyranosyl unit rather than 2-O-methyl-alpha-L-rhamnopyranose.
机译：表征牛分枝杆菌大多数分离物的糖脂已被称为牛分枝杆菌。鉴定脂质的是文献中其他人描述的酚糖脂霉菌糖苷B。然而，当详细检查从牛分枝杆菌BCG，田间分离株和感染组织获得的霉菌苷B时，在某些重要方面与文献中描述的有所不同。特别地，糖基取代基是2-O-甲基-α-L-鼠李吡喃糖而不是2-O-甲基-β-D-鼠李吡喃糖。利用该信息，合成了适用于牛结核病血清诊断的具有2-O-甲基-α-L-鼠李糖基取代基的血清反应性新糖蛋白（新抗原）。牛分枝杆菌还含有其他次要的血清反应性酚类糖脂，其中一种是霉菌苷B的去酰化形式，另一种含有α-L-鼠李糖基吡喃糖基单元而不是2-O-甲基-α-L-鼠李糖基吡喃糖。

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