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首页> 外文期刊>Infection and immunity >Genetic relationships among strains of avian Escherichia coli associated with swollen-head syndrome.
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Genetic relationships among strains of avian Escherichia coli associated with swollen-head syndrome.

机译：与头肿综合征相关的禽大肠杆菌菌株之间的遗传关系。

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Genetic diversity among 22 Escherichia coli strains isolated from chickens with swollen-head syndrome (SHS), an acute respiratory disease of domestic poultry, and 93 strains isolated from birds with colibacillosis was assessed on the basis of allelic variation at 20 enzyme-encoding loci detected by multilocus enzyme electrophoresis. SHS isolates from Spain and Canada were polymorphic at 14 loci and were classified into 19 multilocus genotypes, defining clones that differed on average at 34% of the loci. In most cases, SHS isolates of different clonal genotypes were distinct in O:H serotype and expressed different fimbrial antigens. Comparisons with 93 isolates obtained from birds with colibacillosis revealed enzyme polymorphisms at 17 of 20 loci, with an average of 3.5 alleles per locus. In the total sample, 56 clonal genotypes were distinguished, with 27 (23%) of the isolates belonging to one of three common clones. Both SHS and colibacillosis isolates were genetically diverse, with an average single-locus diversity of 0.36, indicating that a wide variety of naturally occurring bacterial clones is associated with these acute avian infections. Six previously defined groups of clones identified in diseased birds from the United States were represented in isolates from Spain, indicating that similar clones occur in widely separated geographic areas. In addition, one group of SHS isolates was closely related to a recognized widespread clone complex incriminated in human septicemia and meningitis. The results suggest that certain strains implicated in SHS infections belong to a clone complex whose members have special attributes that promote involvement in invasive diseases in humans and animals.
机译：根据检测到的20个酶编码基因座的等位基因变异，评估了22株从急性家禽呼吸道疾病家禽浮肿综合征鸡中分离出的22株大肠杆菌的遗传多样性。通过多位酶电泳。来自西班牙和加拿大的SHS分离株在14个基因座处具有多态性，并被分类为19个多基因座基因型，定义了平均差异为基因座34％的克隆。在大多数情况下，不同克隆基因型的SHS分离株在O：H血清型中截然不同，并表达不同的纤维抗原。与从患有大肠杆菌病的鸟类中获得的93种分离株进行比较后，发现20个基因座中有17个具有酶多态性，每个基因座平均有3.5个等位基因。在总样本中，区分出56个克隆基因型，其中27个（23％）分离株属于三个常见克隆之一。 SHS和大肠埃希菌病分离株均具有遗传多样性，平均单基因座多样性为0.36，这表明多种天然存在的细菌克隆与这些急性禽感染有关。在来自美国的患病鸟类中鉴定出的六种先前定义的克隆以西班牙的分离株为代表，表明相似的克隆发生在广泛分离的地理区域中。此外，一组SHS分离株与公认的广泛存在于人类败血病和脑膜炎中的克隆复合体密切相关。结果表明，与SHS感染有关的某些菌株属于克隆复合体，其成员具有促进参与人类和动物侵袭性疾病的特殊属性。

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