Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.

K A Rockett; M M Awburn; W B Cowden; I A Clark

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Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.

机译：一氧化氮衍生物在体外杀死恶性疟原虫。

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We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.

机译：我们已经研究了人类疟疾寄生虫恶性疟原虫对一氧化氮和相关分子杀伤的体外敏感性。一氧化氮的饱和溶液不会抑制寄生虫的生长，但是一氧化氮的两种氧化产物（亚硝酸盐和硝酸根离子）对毫摩尔浓度的寄生虫有毒。发现半胱氨酸和谷胱甘肽的亚硝基硫醇衍生物的活性（亚硝酸盐）比亚硝酸盐的活性高约一千倍（50％生长抑制浓度，约40 microM）。

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《Infection and immunity》 |1991年第9期|共4页
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K A Rockett; M M Awburn; W B Cowden; I A Clark;
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中图分类医学免疫学;
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Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.

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