A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice.

T A Mietzner; J F Kokai-Kun; P C Hanna; B A McClane

首页> 外文期刊>Infection and immunity >A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice.

【24h】

A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice.

机译：对应于A型产气荚膜梭菌肠毒素C末端区域的缀合的合成肽在小鼠中引起肠毒素中和抗体应答。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A synthetic peptide homolog corresponding to the C-terminal 30 amino acids of Clostridium perfringens type A enterotoxin (CPE) was conjugated to a thyroglobulin carrier and used to immunize mice. Conjugate-immunized mice produced antibodies which neutralized native CPE cytotoxicity, at least in part, by blocking enterotoxin binding. This peptide may be useful for the development of a vaccine to protect against CPE-mediated disease.

机译：将对应于产气荚膜梭状芽孢杆菌肠毒素（CPE）的C端30个氨基酸的合成肽同系物与甲状腺球蛋白载体偶联，并用于免疫小鼠。结合免疫的小鼠产生的抗体至少部分通过阻断肠毒素结合而中和了天然CPE的细胞毒性。该肽可用于开发疫苗以预防CPE介导的疾病。

著录项

来源
《Infection and immunity》 |1992年第9期|共5页
作者
T A Mietzner; J F Kokai-Kun; P C Hanna; B A McClane;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4 [J] . Takahashi A, Kondoh M, Masuyama A, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2005,第1期

机译：产气荚膜梭菌肠毒素C末端片段C末端区域在与claudin-4相互作用中的作用
2. A Synthetic Peptide Corresponding to the Extracellular Loop 2 Region of Claudin-4 Protects against Clostridium perfringens Enterotoxin In Vitro and In Vivo [J] . Archana Shrestha, Susan L. Robertson, Jorge Garcia, Infection and immunity . 2014,第11期

机译：对应于Claudin-4胞外环2区域的合成肽可在体外和体内保护产气荚膜梭菌肠毒素
3. Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. [J] . Takahashi A, Komiya E, Kakutani H, Biochemical Pharmacology . 2008,第8期

机译：通过定点诱变，claudin-4调节剂（产气荚膜梭菌肠毒素的C末端片段的C末端区域的C末端区域）的结构域作图。
4. A Self-assembled Peptide-based Adjuvant Eliciting Strong Antibody Responses with Minimal Inflammation [C] . Rebecca R. Pompano, Jianjun Chen, Jai S. Rudra, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：一种自组装的基于肽的佐剂，可产生强烈的抗体反应，并具有最小的炎症反应
5. EFFECT OF LOW-DOSE GAMMA IRRADIATION ON ENTEROTOXIN POSITIVE STRAINS OF CLOSTRIDIUM PERFRINGENS TYPE A [D] . BARNHART, HAROLD MELVIN, JR. 1976

机译：低剂量伽马射线辐照对A型梭状芽胞杆菌肠毒素阳性菌株的影响
6. A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice. [O] . T A Mietzner, J F Kokai-Kun, P C Hanna, 1992

机译：对应于A型产气荚膜梭菌肠毒素C末端区域的缀合的合成肽在小鼠中引起肠毒素中和抗体应答。
7. Analysis of Multiple Antigenic Determinants of Clostridium perfringens Enterotoxin as Revealed by Use of Different Synthetic Peptides. [O] . Shunji SUGII 1994

机译：用不同合成肽揭示的梭菌梭菌梭菌多抗原决定因素分析。
8. Specific Antibody Against 'Clostridium perfringens' Type A Enterotoxin in Chinese on Taiwan. [R] . Tsai, C. C., Jong, Y. M., Hsieh, Y. H., 1976

机译：台湾地区“产气荚膜梭菌”a型肠毒素特异性抗体。

A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice.

摘要

著录项

相似文献

相关主题

期刊订阅