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首页> 外文期刊>Infection and immunity >Iron starvation causes release from the group A streptococcus of the ADP-ribosylating protein called plasmin receptor or surface glyceraldehyde-3-phosphate-dehydrogenase.
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Iron starvation causes release from the group A streptococcus of the ADP-ribosylating protein called plasmin receptor or surface glyceraldehyde-3-phosphate-dehydrogenase.

机译：铁饥饿导致ADP-核糖基化蛋白（称为纤溶酶受体）或表面甘油醛-3-磷酸-脱氢酶的A组链球菌释放。

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摘要

In many pathogenic bacteria, iron starvation serves as an environmental signal that triggers the expression of virulence factors, many of which are found on the cell surface or secreted into the culture supernatant. Using the chelating agent nitrilotriacetic acid, we have established conditions for iron starvation of the important human pathogen Streptococcus pyogenes (the group A streptococcus) and determined that iron limitation results in the specific appearance of several new proteins in the culture supernatant. One of these supernatant proteins is the ADP-ribosylating protein known as streptococcal plasmin receptor (Plr) or as the streptococcal surface glyceraldehyde-3-phosphate-dehydrogenase because of its other activities. Upon iron starvation, Plr is specifically released into the culture supernatant in a time-dependent manner, and its appearance in the supernatant is not accompanied by induction of plr mRNA synthesis. Release of Plr from the bacteria may be important for the virulence of group A streptococci and the manifestation of diseases.
机译：在许多病原细菌中，铁饥饿是一种环境信号，可触发毒力因子的表达，其中许多因子在细胞表面发现或分泌到培养上清液中。使用螯合剂次氮基三乙酸，我们为重要的人类病原体化脓性链球菌（A族链球菌）铁饥饿提供了条件，并确定了铁限制导致培养上清液中几种新蛋白质的特定外观。这些上清蛋白之一是ADP-核糖基化蛋白，因其其他活性而被称为链球菌纤溶酶受体（Plr）或链球菌表面甘油醛-3-磷酸脱氢酶。在铁饥饿时，Plr以时间依赖性方式特异性地释放到培养物上清液中，并且它在上清液中的出现不会伴随着plr mRNA合成的诱导。从细菌中释放Plr可能对A组链球菌的毒力和疾病的表现很重要。

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