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首页> 外文期刊>Infection and immunity >Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis
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Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis

机译：Bancroftian丝虫病的抗基因和非抗基因个体中细胞因子产生细胞的频率差异

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Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from aWuchereria bancrofti-endemic area of Brazil were classified as being asymptomatic microfilaremic individuals, antigenemic individuals with clinical filariasis, or nonantigenemic individuals with clinical filariasis. Intracellular cytokine staining of mitogen-stimulated peripheral blood mononuclear cells (PBMC) showed that the frequency of either gamma interferon (IFN-γ)- or interleukin-4 (IL-4)-producing cells was higher in the nonantigenemic individuals with clinical filariasis than in the asymptomatic microfilaremic individuals (geometric means, 22.1 versus 10.7% [P = 0.02] and 2.9 versus 1.4% [P= 0.01], respectively). When the asymptomatic microfilaremic individuals and antigenemic individuals with clinical filariasis were grouped together to constitute all actively infected individuals, the frequency of IFN-γ-producing cells was also lower than in the nonantigenemic individuals with clinical filariasis (P= 0.04). Likewise, the frequency of IL-4-producing cells in the actively infected individuals was also lower than in the nonantigenemic individuals with clinical filariasis (P = 0.02). No differences in the frequency of IFN-γ-, IL-4-, or IL-5-producing cells in purified CD4 T lymphocytes were found among the groups. These findings suggest that the presence of antigenemia, which is an indicator of current active infection, is closely associated with the frequency of IFN-γ- and IL-4-producing cells in lymphatic filariasis. The differences found in the frequency of cytokine-producing cells among the three groups appear to be due to a subset of cells other than CD4 T cells.
机译：具有淋巴丝虫病临床表现的个人目前可能尚未感染。来自巴西的Wuchereria bancrofti流行地区的二十五个个体被分类为无症状的微丝虫病个体，具有临床丝虫病的抗原性个体或具有临床丝虫病的非抗原性个体。有丝分裂原刺激的外周血单核细胞（PBMC）的细胞内细胞因子染色显示，在临床上有丝虫病的非抗原性个体中，γ干扰素（IFN-γ）或白介素4（IL-4）产生细胞的频率高于无症状的微丝虫个体（几何平均值分别为22.1对10.7％[ P = 0.02]和2.9对1.4％[ P = 0.01]）。当将无症状的微丝虫病个体和具有临床丝虫病的抗原性个体组合在一起构成所有活跃感染的个体时，产生IFN-γ的细胞的频率也低于具有临床丝虫病的非抗原性个体（ P = 0.04）。同样，活跃感染个体中产生IL-4的细胞的频率也低于具有临床丝虫病的非抗基因个体（ P = 0.02）。各组之间在纯化的CD4 T淋巴细胞中未发现产生IFN-γ-，IL-4-或IL-5的细胞的频率差异。这些发现表明，抗原血症的存在与当前淋巴丝虫病中产生IFN-γ和IL-4的细胞的频率密切相关，抗原血症是当前活跃感染的指示。三组中产生细胞因子的细胞的频率差异似乎是由于CD4 T细胞以外的一部分细胞所致。

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