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Susceptibility of Epithelial Cells to Pseudomonas aeruginosa Invasion and Cytotoxicity Is Upregulated by Hepatocyte Growth Factor

机译:肝细胞生长因子上调上皮细胞对铜绿假单胞菌侵袭的敏感性和细胞毒性

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Normal cell polarity protects epithelial cells againstPseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.
机译:正常细胞极性可保护上皮细胞免受铜绿假单胞菌的侵袭和细胞毒性。使用在膜成分的排序中具有选择性缺陷的上皮细胞克隆,以及使用肝细胞生长因子预处理,我们发现对 P的极化敏感性。铜绿假单胞菌可以改变而不会破坏紧密的连接。结果还表明,尽管细胞和细胞毒性均位于极化上皮细胞的基底外侧细胞表面,但细胞对侵袭和细胞毒性的敏感性因子并不相同。

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