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首页> 外文期刊>Infection and immunity >Susceptibility to Salmonella typhimurium Infection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor
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Susceptibility to Salmonella typhimurium Infection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor

机译：鼠坏死沙门氏菌感染的易感性和肿瘤坏死因子αp55受体缺乏症的小鼠的疫苗接种的有效性。

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摘要

Mice defective in the ability to produce the tumor necrosis factor alpha p55 receptor (TNFαp55R) were orally challenged with a number ofSalmonella typhimurium HWSH derivatives that differ in virulence. In comparison to TNFαp55R+/+ mice, TNFαp55R?/? mice succumbed earlier to challenge with wild-type S. typhimurium HWSH and S. typhimurium HWSH purE. In contrast, TNFαp55R?/? mice were able to control anS. typhimurium HWSH aroA challenge, although greater numbers of Salmonella organisms were present in the tissues for a longer time period than was observed with TNFαp55R+/+ mice. Vaccination of normal and TNFαp55R knockout animals with S. typhimurium HWSH aroA showed that TNFαp55R?/? mice, unlike TNFαp55R+/+ mice, were not protected against a virulent S. typhimurium HWSH challenge. Splenocytes from TNFαp55R?/? mice exhibited a reduced ability to proliferate in the presence of S. typhimuriumantigen compared to TNFαp55R+/+ mice. Thus, TNFαp55R is essential for controlling Salmonellagrowth in tissues and for recall of immunity in murine salmonellosis.
机译：用多种毒力不同的鼠伤寒沙门氏菌 HWSH衍生物口服攻击产生肿瘤坏死因子αp55受体（TNFαp55R）能力不足的小鼠。与TNFαp55R + / + 小鼠相比，TNFαp55R？/？小鼠更易受野生型 S攻击。鼠伤寒 HWSH和 S。鼠伤寒 HWSH purE 。相反，TNFαp55R？/？小鼠能够控制 S。鼠伤寒 HWSH aroA 攻击，尽管与TNFαp55R + / +相比，组织中存在更多的沙门氏菌生物小鼠。用 S接种正常和TNFαp55R基因敲除动物。鼠伤寒 HWSH aroA 表明，TNFαp55R？/？小鼠与TNFαp55R + / + 小鼠不同，没有针对强毒的< em> S。鼠伤寒 HWSH挑战。 TNFαp55R？/？小鼠的脾细胞在 S存在下增殖能力降低。鼠伤寒沙门氏菌抗原与TNFαp55R + / + 小鼠相比。因此，TNFαp55R对于控制组织中的沙门氏菌生长和召回鼠沙门氏菌病的免疫力至关重要。

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