Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis

Karl B. Seydel; Samuel L. Stanley

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Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis

机译：Entamoeba histolytica通过非Fas依赖，非肿瘤坏死因子α依赖的凋亡途径诱导阿米巴肝脓肿中的宿主细胞死亡。

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Amebic liver abscess is characterized by extensive areas of dead hepatocytes that form cavities surrounded by a thin rim of inflammatory cells and few Entamoeba histolytica trophozoites. E. histolytica produces pore-forming proteins and proteinases, but how trophozoites actually kill host cells has been unclear. Here, we report that E. histolytica induces apoptosis in both inflammatory cells and hepatocytes in a severe combined immunodeficient (SCID) mouse model of amebic liver abscess. By studying infection in C57/BL6.lpr and C57/BL6.gld mice, we found that E. histolytica-induced apoptosis does not require the Fas/Fas ligand pathway of apoptosis, and by using mice with a targeted deletion of the tumor necrosis factor receptor I gene, we have shown that E. histolytica-induced apoptosis is not mediated by tumor necrosis factor alpha. Our data indicate that apoptosis plays a prominent role in the host cell death seen in amebic liver abscess in a mouse model of disease and suggest that E. histolytica induces cell death without using two common pathways for apoptosis.

机译：阿米巴肝脓肿的特征是死细胞的广泛区域形成死腔，周围被炎性细胞的薄边缘和少量的溶血滋养体包围。 E。 histolytica 产生孔形成蛋白和蛋白酶，但滋养体如何杀死宿主细胞尚不清楚。在这里，我们报告 E。在溶血性阿米巴脓肿的严重联合免疫缺陷（SCID）小鼠模型中，组织溶菌诱导炎性细胞和肝细胞凋亡。通过研究C57 / BL6.lpr和C57 / BL6.gld小鼠的感染，我们发现 E。组织溶菌诱导的凋亡不需要凋亡的Fas / Fas配体途径，通过使用具有肿瘤坏死因子受体I基因靶向缺失的小鼠，我们证明了 E。组织坏死因子诱导的细胞凋亡不是由肿瘤坏死因子α介导的。我们的数据表明凋亡在疾病小鼠模型的阿米巴肝脓肿中的宿主细胞死亡中起着重要作用，并提示 E。 histolytica 诱导细胞死亡，而没有使用两种常见的凋亡途径。 展开▼

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《Infection and immunity》 |1998年第6期|共4页

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Karl B. Seydel; Samuel L. Stanley;
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中图分类医学免疫学;

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1. Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis [J] . Karl B. Seydel, Samuel L. Stanley Infection and immunity . 1998,第6期

机译：Entamoeba histolytica通过非Fas依赖，非肿瘤坏死因子α依赖的凋亡途径诱导阿米巴肝脓肿中的宿主细胞死亡。

2. Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess [J] . Armando Isibasi, Artur J. Ulmer, Buko Lindner, PLoS Pathogens . 2009,第5期

机译：从溶血性变形虫中脂肽磷酸聚糖激活的自然杀伤T细胞对于控制阿米巴性肝脓肿至关重要

3. Diagnosis of Amebic Liver Abscess and Amebic Colitis by Detection of Entamoeba histolytica DNA in Blood, Urine, and Saliva by a Real-Time PCR Assay [J] . Rashidul Haque, Mamun Kabir, Zannatun Noor, Journal of Clinical Microbiology . 2010,第8期

机译：通过实时PCR检测血液，尿液和唾液中溶组织性变形杆菌DNA，诊断阿米巴肝脓肿和阿米巴结肠炎

4. Entamoeba Histolytica Strain with a Non-described Chitinase Genotype in Mexican Patients with Amoebic Liver Abscess [C] . F. Ramos, G. Garcia, A. Valadez, European Congress on Tropical Medicine and International Health . 2007

机译：Entamoeba组织菌株菌株在墨西哥患者患有非描述的胰蛋白酶基因型患者Amoebic肝脏脓肿

5. Apoptosis and the pathophysiology of amebic liver abscess. [D] . Pelosof, Lorraine Cheryl. 2007

机译：阿米巴肝脓肿的凋亡与病理生理。

6. Note: Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis [O] . Karl B. Seydel, Samuel L. Stanley Jr. 1998

机译：注意：Entamoeba histolytica通过非Fas依赖性非肿瘤坏死因子α依赖性凋亡途径诱导阿米巴肝脓肿中宿主细胞死亡。

7. Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis [O] . Karl B. Seydel, Samuel L. Stanley 1998

机译：entamoeba histolytica通过非Fas依赖性的非肿瘤坏死因子α-凋亡途径在琥珀肝脓肿中诱导宿主细胞死亡

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2. 雄激素依赖/非依赖性前列腺癌中高表达的人蛋白在前列腺肿瘤诊断、治疗预后中的新用途 [P] . 中国专利： CN1775952A . 2006-05-24

3. Multispecies and multivalent Binding Protein that binds to Tumor Necrosis Factor (TNF) and weak Inducer of Apoptosis tumor necrosis factor related (TWEAK); conjugated uniOn the Protein and Nucleic Acid Coding; vector and Cell comprising Said nucleic acid and Method for producing such a Pharmaceutical composition comprising Said Protein; Protein [P] . 外国专利： CL2012003610A1 . 2013-05-17

机译：与肿瘤坏死因子（TNF）和细胞凋亡弱诱导物相关的多物种和多价结合蛋白，与肿瘤坏死因子相关（TWEAK）;蛋白质和核酸编码的共轭单载体和包含所述核酸的细胞以及制备包含所述蛋白质的药物组合物的方法;蛋白

4. compounds, pharmaceutical composition, method for treating a cell proliferative disorder, method for treating a neurological disorder, methods for inhibiting one or more kinases, method for inhibiting cell proliferation of cancer cells, method for inducing cancer cell death, method for to induce apoptosis of cancer cells, method to induce apoptosis in a cell and methods to produce compounds [P] . 外国专利： BR112013027787A2 . 2017-06-27

机译：化合物，药物组合物，治疗细胞增生性疾病的方法，治疗神经性疾病的方法，抑制一种或多种激酶的方法，抑制癌细胞的细胞增殖的方法，诱导癌细胞死亡的方法，诱导细胞凋亡的方法癌细胞，诱导细胞凋亡的方法和产生化合物的方法

5. methods of reversing or preventing the resistance of a cell to a death receptor agonist, of screening a cell for a biomarker of resistance to a death receptor agonist, of monitoring resistance to a death receptor agonist in an individual , to selectively induce apoptosis in a target cell expressing a death receptor, to treat an individual with cancer, to treat an individual with an inflammatory or autoimmune disease, to block the binding of the card-containing protein to a death receptor in a cell, to block the association of an iap with the death receptor and to screen a modulator of a protein containing card, composition, isolated nucleic acid, vector, cell, and isolated polypeptide [P] . 外国专利： BRPI0606791A2 . 2010-02-09

机译：逆转或预防细胞对死亡受体激动剂的抗性的方法，为细胞筛选对死亡受体激动剂的抗性的生物标志物，监测个体对死亡受体激动剂的抗性，以选择性地诱导靶标中的细胞凋亡的方法表达死亡受体的细胞，治疗患有癌症的个体，治疗患有炎性或自身免疫性疾病的个体，阻止含卡蛋白与细胞中死亡受体的结合，阻止iap与死亡受体并筛选蛋白质的调节剂，该蛋白质包含卡片，成分，分离的核酸，载体，细胞和分离的多肽

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Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis

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