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首页> 外文期刊>Infection and immunity >Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity
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Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

机译：侵入性A组链球菌感染的发病机制中的危险因素：保护性体液免疫的作用。

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An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery—has there been a change in the pathogen or in host protective immunity? To address these questions, we have studied 33 patients with invasive infection caused by genotypically indistinguishable M1T1 strains of Streptococcus pyogenes who had different disease outcomes. Patients were classified as having severe (n= 21) and nonsevere (n = 12) invasive infections based on the presence or absence of shock and organ failure. Levels of anti-M1 bactericidal antibodies and of anti-streptococcal superantigen neutralizing antibodies in plasma were significantly lower in both groups than in age- and geographically matched healthy controls (P < 0.01). Importantly, the levels of these protective antibodies in plasma samples from severe and nonsevere invasive cases were not different. Together the data suggest that low levels of protective antibodies may contribute to host susceptibility to invasive streptococcal infection but do not modulate disease outcome. Other immunogenetic factors that regulate superantigen responses may influence the severity of systemic manifestations associated with invasive streptococcal infection.
机译：在1980年代，侵袭性A组链球菌感染的流行病学和严重程度发生了令人印象深刻的变化，并且链球菌中毒性休克综合征病例的发生率继续上升。重度侵入性病例再次流行的原因仍然是一个谜-病原体或宿主保护性免疫是否发生了变化？为解决这些问题，我们研究了33例由化脓性链球菌（emem）的M1T1基因型无法区分的侵袭性感染患者，这些患者具有不同的疾病结局。根据是否存在休克和器官衰竭，将患者分为严重（ n = 21）和不严重（ n = 12）侵袭性感染。两组中血浆中抗M1杀菌抗体和抗链球菌超抗原中和抗体的水平均显着低于年龄和地理位置相匹配的健康对照组（ P <0.01）。重要的是，来自严重和非严重侵入性病例的血浆样品中这些保护性抗体的水平没有差异。数据共同表明，低水平的保护性抗体可能有助于宿主对侵袭性链球菌感染的敏感性，但不会调节疾病的预后。调节超抗原反应的其他免疫遗传因素可能会影响与侵袭性链球菌感染相关的全身表现的严重性。

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