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首页> 外文期刊>Infection and immunity >Lack of CD4+ T Cells Does Not Affect Induction of CD8+ T-Cell Immunity against Encephalitozoon cuniculi Infection
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Lack of CD4+ T Cells Does Not Affect Induction of CD8+ T-Cell Immunity against Encephalitozoon cuniculi Infection

机译：CD4 + T细胞的缺乏并不影响针对库氏脑炎感染的CD8 + T细胞免疫诱导。

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Cell-mediated immunity has been reported to play an important role in defense against Encephalitozoon cuniculi infection. Previous studies from our laboratory have underlined the importance of cytotoxic CD8+ T lymphocytes (CTL) in survival of mice infected with E. cuniculi. In the present study, immune response against E. cuniculi infection in CD4+T-cell-deficient mice was evaluated. Similar to resistant wild-type animals, CD4?/? mice were able to resolve E. cuniculi infection even at a very high challenge dose (5 × 107 spores/mouse). Tissues from infected CD4?/? mice did not exhibit higher parasite loads in comparison to the parental wild-type mice. Conversely, at day 21 postinfection, susceptible CD8?/? mice had 1014 times more parasites in the liver compared to control wild-type mice. Induction of the CD8+ T-cell response in CD4?/? mice against E. cuniculi infection was studied. Interestingly, a normal antigen-specific CD8+T-cell response to E. cuniculi infection was observed in CD4?/? mice (precursor proliferation frequency, 1/2.5 × 104 versus 1/104 in wild-type controls). Lack of CD4+ T cells did not alter the magnitude of the antigen-specific CTL response (precursor CTL frequency; 1/1.4 × 104 in CD4?/? mice versus 1/3 × 104 in control mice). Adoptive transfer of immune CD8+ T cells from both CD4?/? and wild-type animals prevented the mortality in CD8?/? mice.E. cuniculi infection thus offers an example of an intracellular parasitic infection where CD8+ T-cell immunity can be induced in the absence of CD4+ T cells.
机译：据报道，细胞介导的免疫在防御 cubiculi cuniculi 感染中起重要作用。我们实验室的先前研究强调了细胞毒性CD8 + T淋巴细胞（CTL）在感染 E的小鼠的存活中的重要性。 cuniculi 。在本研究中，针对 E的免疫反应。评价CD4 + T细胞缺陷型小鼠的尾nic感染。与抗性野生型动物相似，CD4 ？/？小鼠能够分辨 E。即使在很高的激发剂量（5×10 7 孢子/小鼠）下也可感染铜霉菌。与亲本野生型小鼠相比，感染的CD4 α/β小鼠的组织没有表现出更高的寄生虫负荷。相反，在感染后第21天，与对照组野生型小鼠相比，易感CD8 α/？小鼠的肝脏中寄生虫多10 14 倍。 CD4 ？/？小鼠对 E的CD8 + T细胞应答的诱导。研究了cuniculi 感染。有趣的是，正常的抗原特异性CD8 + T细胞对 E的反应。在CD4 ？/？小鼠中观察到cuniculi 感染（前体增殖频率为1 / 2.5×10 4 相对于1/10 4 >（在野生型控件中）。缺乏CD4 + T细胞并没有改变抗原特异性CTL反应的强度（前体CTL频率; CD4 ？/中的1 / 1.4×10 4 ？小鼠与对照组的1/3×10 4 相比）。免疫性CD8 + T细胞从CD4 ？/？和野生型动物的过继转移阻止了CD8 ？/？小鼠的死亡。 E。因此，cuniculi 感染提供了一种细胞内寄生虫感染的例子，其中可以在没有CD4 + T细胞的情况下诱导CD8 + T细胞免疫。

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