Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice

Masaru Ando; Tetsuyuki Yoshimatsu; Chiew Ko; Paul J. Converse; William R. Bishai

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Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice

机译：结核分枝杆菌西格玛因子E的删除导致气溶胶感染小鼠肺部细菌持久性死亡时间的延迟。

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The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

机译：应激诱导的结核分枝杆菌的胞浆外σ因子（SigE）在热休克，十二烷基硫酸钠处理，氧化应激以及巨噬细胞吞噬作用后均表达增加。我们报告说， sigE 的删除导致小鼠的致死性延迟，而肺中细菌数量没有明显减少。 展开▼

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《Infection and immunity》 |2003年第12期|共3页

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Masaru Ando; Tetsuyuki Yoshimatsu; Chiew Ko; Paul J. Converse; William R. Bishai;
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中图分类医学免疫学;

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1. Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice [J] . Masaru Ando, Tetsuyuki Yoshimatsu, Chiew Ko, Infection and immunity . 2003,第12期

机译：结核分枝杆菌西格玛因子E的删除导致气溶胶感染小鼠肺部细菌持久性死亡时间的延迟。

2. Deletion of the Mycobacterium tuberculosis Resuscitation-Promoting Factor Rv1009 Gene Results in Delayed Reactivation from Chronic Tuberculosis [J] . JoAnn M. Tufariello, Kaixia Mi, Jiayong Xu, Infection and immunity . 2006,第5期

机译：结核分枝杆菌复苏促进因子Rv1009基因的删除导致慢性结核病的延迟激活。

3. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set [J] . Sun RG., Converse PJ., Ko C., Molecular Microbiology . 2004,第1期

机译：结核分枝杆菌ECFσ因子sigC是小鼠致死率和条件表达定义的基因组所必需的

4. ARE BACTERIAL LECTINS IMPORTANT FOR TUBERCULOSIS? INVESTIGATION OF THE CARBOHYDRATE BINDING SPECIFICITY OF MYCOBACTERIUM TUBERCULOSIS [C] . Kolbe K., Lindhorst T. K. International Carbohydrate Symposium . 2013

机译：是结核病重要的细菌凝集素吗？调查结核分枝杆菌的碳水化合物结合特异性

5. In vivo analysis of factors affecting the dynamics of the adaptive immune response to Mycobacterium tuberculosis and contributing to bacterial persistence. [D] . Wolf, Andrea J. 2008

机译：在体内分析影响结核分枝杆菌适应性免疫反应动力学并促进细菌持久性的因素。

6. Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice [O] . Masaru Ando, Tetsuyuki Yoshimatsu, Chiew Ko, 2003

机译：删除中结核分枝杆菌Sigma因子E的检测肺中细菌持续存在导致死亡时间延迟气溶胶感染老鼠

7. Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice [O] . Ando, Masaru, Yoshimatsu, Tetsuyuki, Ko, Chiew, 2003

机译：删除中结核分枝杆菌Sigma因子E的检测肺中细菌持续存在导致死亡时间延迟气溶胶感染老鼠

1. 029 缺失Sigma E因子的结核分枝杆菌可推迟感染小鼠的死亡期 [J] . . 微生物与感染 . 2004,第005期

2. 布鲁菌液体气溶胶肺部感染途径小鼠模型建立及毒理评价 [J] . 韦超 ,杨文慧 ,周冬生 . 传染病信息 . 2018,第003期

3. EB病毒相关的复发性坏死性丘疱疹伴反复细菌感染导致败血症和死亡:EB病毒感染与免疫缺陷间的相关性 [J] . . 国际皮肤性病学杂志 . 2002,第004期

4. 结核病人感染人类免疫缺陷病毒导致血浆中和结核分枝杆菌诱生的细胞因子变化 [J] . 孟玉芬 ,黄瑞 . 微生物与感染 . 2004,第004期

5. 细胞因子对小鼠结核分枝杆菌感染的免疫保护作用 [J] . 汤红明 ,刘君炎 . 现代检验医学杂志 . 2008,第004期

6. 急诊COPD死亡患者肺部感染分析及影响生存时间的危险因素探讨 [C] . 杨展正 ,李锦银 ,刘荣 . 2015第十一届全国中西医结合灾害医学大会暨江苏省中西医结合学会第二届灾害医学学术会议 . 2015

7. 基于MAPK信号传导通路探讨清肺培元颗粒对免疫低下肺部细菌感染BALB/C小鼠的影响 [A] . 黄冠 . 2014

1. Detection of Non-tuberculosis Mycobacterium Mycobacterium tuberculosis and Multidrug-resistant Mycobacterium tuberculosis using real-time polymerase chain reaction and melting temperature measurement [P] . 外国专利： KR102123621B1 . 2020-06-16

机译：实时聚合酶链反应和熔解温度检测检测非结核分枝杆菌结核分枝杆菌和耐多药结核分枝杆菌

2. Detection of Non-tuberculosis Mycobacterium, Mycobacterium tuberculosis, and Multidrug-resistant Mycobacterium tuberculosis using real-time polymerase chain reaction and melting temperature measurement [P] . 外国专利： KR1021236210000B1 . 2020.06.16

3. Stationary phase, stress response sigma factor from mycobacterium tuberculosis, and regulation thereof [P] . 外国专利： AU732858B2 . 2001-05-03

机译：静止期，结核分枝杆菌的应激反应σ因子及其调节

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Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice

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