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首页> 外文期刊>Infection and immunity >Interleukin-18 Is an Essential Element in Host Resistance to Experimental Group B Streptococcal Disease in Neonates
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Interleukin-18 Is an Essential Element in Host Resistance to Experimental Group B Streptococcal Disease in Neonates

机译：白细胞介素18是宿主对新生儿实验性B组链球菌疾病的抗性的基本要素。

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Previous studies demonstrated that interleukin-12 (IL-12)-dependent gamma interferon (IFN-γ) responses have a major role in restricting in vivo bacterial growth during infection of mice with group B streptococci (GBS), important human pathogens. Like IL-12, IL-18 is a potent IFN-γ inducer. The role of IL-18 in experimental GBS infection was investigated here. Significant elevations of IL-18 levels over baseline values were detected in plasma samples from neonatal mice rendered septic with GBS. Neutralization of IL-18 significantly increased mortality and bacterial burden (P < 0.05). In contrast, administration of recombinant IL-18 (rIL-18) before or after GBS challenge remarkably improved survival and decreased blood colony counts, in association with increased IFN-γ production by spleen cells. The beneficial effects of rIL-18 were counteracted by administration of neutralizing anti-IFN-γ monoclonal antibodies, indicating that the effects of IL-18 were mediated by IFN-γ. Finally, low rIL-18 doses that had no effect of their own on bacterial burden could act in synergy with rIL-12 to protect neonatal mice during GBS infection. Collectively, our data indicate that IL-18 responses have an important role in host defenses against GBS and that rIL-18 may be useful in alternative strategies to treat neonatal GBS disease.
机译：先前的研究表明，白细胞介素12（IL-12）依赖性γ干扰素（IFN-γ）反应在限制B族链球菌（GBS）（一种重要的人类病原体）的小鼠感染过程中，在限制体内细菌生长中起着重要作用。像IL-12一样，IL-18是有效的IFN-γ诱导剂。在此研究了IL-18在实验性GBS感染中的作用。在GBS化脓性新生小鼠血浆样品中检测到IL-18水平明显高于基线水平。 IL-18的中和显着增加了死亡率和细菌负担（ P <0.05）。相反，在GBS刺激之前或之后施用重组IL-18（rIL-18）可以显着提高存活率并减少血菌落数，并与脾细胞产生的IFN-γ增加相关。通过中和抗-IFN-γ单克隆抗体，抵消了rIL-18的有益作用，表明IL-18的作用是由IFN-γ介导的。最后，低剂量的rIL-18对细菌负担没有影响，可以与rIL-12协同作用，在GBS感染期间保护新生小鼠。总体而言，我们的数据表明，IL-18反应在宿主对抗GBS的防御中具有重要作用，而rIL-18可能在治疗新生儿GBS疾病的替代策略中有用。

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