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首页> 外文期刊>Infection and immunity >Effect of abrogation of natural killer cell activity on the course of candidiasis induced by intraperitoneal administration and gastrointestinal candidiasis in mice with severe combined immunodeficiency.
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Effect of abrogation of natural killer cell activity on the course of candidiasis induced by intraperitoneal administration and gastrointestinal candidiasis in mice with severe combined immunodeficiency.

机译：取消自然杀伤细胞活性对严重联合免疫缺陷小鼠腹膜内给药和胃肠道念珠菌病诱导的念珠菌病进程的影响。

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Candida albicans CFU per gram of tissue recovered from livers, spleens, and kidneys of 12 severe combined immunodeficiency (scid) and 12 BALB/c mice 5 days after intraperitoneal (i.p.) administration of 10(7) C. albicans cells were not significantly different. Nine scid mice given normal rabbit serum (NRS) as a control and eight scid mice given anti-asialo-GM1 (alpha-ASGM1) had C. albicans CFU per gram recovered from livers and spleens 1 week after i.p. administration of C. albicans that were not significantly different, despite virtual elimination of natural killer (NK) cell activity in mice treated with alpha-ASGM1. At 2 weeks after i.p. administration, despite significantly increased NK cell activity in eight infected NRS-treated scid mice and virtual elimination of NK cell activity by alpha-ASGM1 treatment of eight scid mice, C. albicans CFU per gram recovered from livers and kidneys were not significantly different. At 2 weeks after intragastric administration of 2 x 10(6) C. albicans cells, eight NRS- and eight alpha-ASGM1-treated scid mice had identical proportions colonized with C. albicans and similar C. albicans CFU per gram recovered from feces. There was no evidence of hematogenous dissemination in either group. Similar results were seen 1 week after intragastric administration of 10(7) C. albicans cells. We conclude that NK cell activity is increased by i.p. administration of C. albicans in scid mice, but nontheless, abrogation of NK cell activity is not associated with enhanced susceptibility to candidiasis induced by i.p. administration and also is not associated with enhanced susceptibility to gastrointestinal colonization or hematogenous dissemination after intragastric administration of C. albicans.
机译：腹腔内（ip）施用10（7）C.白色念珠菌细胞后5天，每克从肝脏，脾脏和肾脏中提取的每克组织念珠菌CFU从12只严重的联合免疫缺陷（scid）和12只BALB / c小鼠的肝脏，脾脏和肾脏回收。腹膜内注射1周后，从正常肝脏血清中提取的9只scid小鼠和每只从肝脏和脾脏中回收的白色念珠菌CFU均接受了白色念珠菌CFU的控制，而这8只scid小鼠接受了抗-asallo-GM1（alpha-ASGM1）的对照组。尽管实际上消除了用alpha-ASGM1处理的小鼠中的自然杀伤（NK）细胞活性，但白色念珠菌的给药没有显着差异。在i.p.之后2周尽管在八只经NRS处理的scid小鼠中NK细胞活性显着增加并且通过八只scid小鼠的alpha-ASGM1处理实际上消除了NK细胞活性，但从肝脏和肾脏中回收的每株白色念珠菌CFU并无显着差异。胃内给药2 x 10（6）白色念珠菌细胞后2周，每克从粪便中回收的NRS和8个经alpha-ASGM1处理的scid小鼠定植相同比例的白色念珠菌和类似白色念珠菌CFU。两组均无血行传播的证据。胃内施用10（7）白色念珠菌细胞1周后，观察到相似的结果。我们得出的结论是，NK细胞的活性通过i.p.增加。在scid小鼠中施用白色念珠菌，但NK细胞活性的废除与i.p.诱导的念珠菌病易感性增加无关。口服给予白色念珠菌后，其与胃肠道定植或血行播散的敏感性增加无关。

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