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首页> 外文期刊>Infection and immunity >Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity.
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Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity.

机译：白喉和破伤风类毒素及百日咳疫苗引起的肝代谢抑制和细胞因子释放的诱导：百日咳博德特氏菌细胞在毒性中的作用。

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摘要

A 24-h pretreatment of mice with diphtheria and tetanus toxoids and whole-cell pertussis vaccines depressed liver cytochrome P-450 and therefore prolonged hexobarbital-induced sleeping time in mice. The depression of liver drug metabolism by a cellular vaccine containing a mutated pertussis toxin was less marked than that induced by the wild-type vaccines, indicating that the mutated vaccine might have lower toxicity in this regard. The wild-type vaccines decreased microsomal P-450 levels by 50%, while the mutated whole-cell vaccine had a less marked effect (a decrease of 30%), paralleling the results obtained in sleeping time experiments. Furthermore, an acellular mutated vaccine did not affect liver drug metabolism, indicating a role of the whole bacterial cell in this side effect. All the cellular vaccines studied induced high serum interleukin-6 levels; on the other hand, the acellular mutated vaccine induced very low interleukin-6 levels, indicating that the whole bacterial cell is also important for interleukin-6 induction. All vaccines studied were very poor tumor necrosis factor inducers.
机译：用白喉和破伤风类毒素以及全细胞百日咳疫苗对小鼠进行的24小时预处理可降低肝细胞色素P-450的含量，因此延长了己糖巴比妥引起的小鼠睡眠时间。含有突变的百日咳毒素的细胞疫苗对肝药物代谢的抑制作用不如野生型疫苗诱导的低，表明该突变疫苗在这方面可能具有较低的毒性。野生型疫苗将微粒体P-450的水平降低了50％，而突变的全细胞疫苗的效果较差（降低了30％），与在睡眠时间实验中获得的结果相似。此外，无细胞突变疫苗不影响肝药物代谢，表明整个细菌细胞在这种副作用中的作用。所有研究的细胞疫苗均诱导高血清白细胞介素6水平。另一方面，脱细胞突变疫苗诱导的白介素6水平非常低，表明整个细菌细胞对白介素6的诱导也很重要。所有研究的疫苗都是非常差的肿瘤坏死因子诱导剂。

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