...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts.
【24h】

Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts.

机译：Shigella spp增加了蛋白质分泌和对HeLa细胞的粘附。在胆盐存在下生长。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Growth of Shigella spp. in the presence of the bile salt deoxycholate or chenodeoxycholate enhanced the bacterial invasion of HeLa cells. Growth in the presence of other structurally similar bile salts or detergents had little or no effect. Deoxycholate-enhanced invasion was not observed when bacteria were exposed to deoxycholate at low temperatures or when chloramphenicol was added to the growth medium, indicating that bacterial growth and protein synthesis are required. Increased invasion is associated with the presence of an intact Shigella virulence plasmid and is correlated with increased secretion of a set of proteins, including the Ipa proteins, to the outer membrane and into the growth medium. The increased invasion induced by the bile salts appears to be due to increased adherence. The enhanced adherence was specific to Shigella spp., since the enteroinvasive Escherichia coli strains tested did not exhibit the effect in response to growth in bile salts.
机译：志贺氏菌的生长。在胆汁盐脱氧胆酸盐或鹅去氧胆酸盐的存在下，可增强HeLa细胞的细菌入侵。在其他结构相似的胆汁盐或去污剂存在下的生长几乎没有影响。当细菌在低温下暴露于脱氧胆酸盐或向生长培养基中添加氯霉素时，未观察到脱氧胆酸盐增强的入侵，表明需要细菌生长和蛋白质合成。侵袭增加与完整的志贺氏菌毒力质粒的存在有关，并且与包括Ipa蛋白在内的一组蛋白质向外膜和向生长培养基的分泌增加有关。胆汁盐引起的浸润增加似乎是由于粘附增加。增强的粘附力是志贺菌的特异性，因为所测试的肠侵袭性大肠杆菌菌株没有表现出对胆盐生长的反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号