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首页> 外文期刊>Infection and immunity >Chronic respiratory mycoplasmosis in C3H/HeN and C57BL/6N mice: lesion severity and antibody response.
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Chronic respiratory mycoplasmosis in C3H/HeN and C57BL/6N mice: lesion severity and antibody response.

机译：C3H / HeN和C57BL / 6N小鼠的慢性呼吸道支原体病：病变严重程度和抗体反应。

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Mycoplasma pneumoniae is a leading, worldwide cause of death and disability due to pneumonia. Mycoplasma pulmonis infection in mice is an invaluable model for the study of host defenses against respiratory mycoplasmas in vivo. C3H/HeN mice are much more susceptible to acute inflammatory lung disease due to M. pulmonis than C57BL/6N mice, but little is known about the chronic disease in these mouse strains. We infected C3H/HeN and C57BL/6N mice with 10(4) CFU of M. pulmonis UAB CT and evaluated them at weekly intervals by quantitative mycoplasma culture of nasal passages, trachea, and lungs, assessment of lesion severity in nasal passages, trachea, and lungs, and determination of serum immunoglobulin classes and subclasses by enzyme-linked immunosorbent assay. We found that C3H/HeN mice had 2 to 5 logs more organisms in their lungs and far more severe lung disease than C57BL/6N mice through 63 days postinfection. Although both strains of mice developed the same classes of antibody, C3H/HeN mice had much greater anti-M. pulmonis immunoglobulin G (IgG) responses in the IgG1 and IgG2a subclasses than C57BL/6N mice. These results suggest that adaptive immunity does not effect resolution of chronic mycoplasma infection and disease in the lungs.
机译：肺炎支原体是全球范围内因肺炎致死和致残的主要原因。小鼠肺炎支原体感染是研究宿主体内抵抗呼吸道支原体的重要模型。与C57BL / 6N小鼠相比，C3H / HeN小鼠更易患肺炎支原体引起的急性炎症性肺病，但对于这些小鼠品系中的慢性疾病知之甚少。我们用10（4）CFU的肺炎支原体UAB CT感染C3H / HeN和C57BL / 6N小鼠，并通过鼻道，气管和肺的定量支原体培养，评估鼻腔，气管的病变严重程度，每周对它们进行评估和肺，以及通过酶联免疫吸附测定法测定血清免疫球蛋白类别和亚类。我们发现，到感染后63天，C3H / HeN小鼠的肺部微生物比C57BL / 6N小鼠多2至5个对数，严重的肺部疾病也更为严重。尽管两种小鼠品系都产生相同类型的抗体，但C3H / HeN小鼠具有更大的抗M抗体。与C57BL / 6N小鼠相比，IgG1和IgG2a亚类中的肺炎免疫球蛋白G（IgG）应答。这些结果表明，适应性免疫不会影响慢性支原体感染和肺部疾病的解决。

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