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首页> 外文期刊>Infection and immunity >Adoptive transfer of T lymphocytes to T-cell-depleted mice inhibits Escherichia coli translocation from the gastrointestinal tract.
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Adoptive transfer of T lymphocytes to T-cell-depleted mice inhibits Escherichia coli translocation from the gastrointestinal tract.

机译：T淋巴细胞过少转移到T细胞缺失小鼠的过继转移抑制了大肠杆菌从胃肠道的移位。

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摘要

Bacterial translocation is defined as the passage of viable bacteria from the gastrointestinal (GI) tract to extraintestinal sites, such as the mesenteric lymph node (MLN), spleen, liver, kidneys, and blood. Previously, we reported that depletion of CD4+ and/or CD8+ T cells promotes bacterial translocation from the GI tract to the MLN. In the present study, CD4+ and/or CD8+ T cells, harvested from donor mice, were adoptively transferred to mice previously depleted of T cells by thymectomy plus intraperitoneal injection of rat anti-mouse T-cell monoclonal antibodies. The adoptively transferred CD4+ and/or CD8+ T cells inhibited the translocation of Escherichia coli from the GI tract. Migration of the adoptively transferred T cells to the spleens and MLNs of the recipient mice was determined by utilizing Thy 1.1+ donor cells adoptively transferred into mice whose cells express the Thy 1.2 marker. These results provide further evidence of the importance of T cells in the host immune defense against bacterial translocation from the GI tract.
机译：细菌移位定义为活细菌从胃肠道（GI）到肠外部位（如肠系膜淋巴结（MLN），脾脏，肝脏，肾脏和血液）的通道。以前，我们报道了CD4 +和/或CD8 + T细胞的耗竭会促进细菌从胃肠道向MLN移位。在本研究中，将从供体小鼠中收获的CD4 +和/或CD8 + T细胞过继转移至先前通过胸腺切除术+腹膜内注射大鼠抗小鼠T细胞单克隆抗体耗尽T细胞的小鼠。过继转移的CD4 +和/或CD8 + T细胞抑制了大肠杆菌从胃肠道的移位。过继转移的T细胞向受体小鼠的脾和MLN的迁移是通过利用过继转移到其细胞表达Thy 1.2标志物的小鼠中的Thy 1.1+供体细胞来确定的。这些结果提供了T细胞在宿主对胃肠道细菌移位的免疫防御中的重要性的进一步证据。

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