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首页> 外文期刊>Infection and immunity >Efficacy of oral vaccination against the murine intestinal parasite Trichuris muris is dependent upon host genetics.
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Efficacy of oral vaccination against the murine intestinal parasite Trichuris muris is dependent upon host genetics.

机译：口服疫苗对鼠肠寄生虫Trichuris muris的功效取决于宿主的遗传学。

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Oral vaccinations with Trichuris muris adult worm homogenate antigen with cholera toxin as the adjuvant were successful in both high-responder BALB/c and low-responder C57BL/10 mice, resulting in high levels of protection against subsequent infection, but were ineffective in the low-responder B10.BR mice. Subcutaneous vaccination with antigen in Freund's complete adjuvant resulted in protection of all of these strains but was most effective in high-responder BALB/c and least effective in B10.BR mice. Oral vaccination resulted in a T. muris-specific intestinal immunoglobulin A response only in the two protected strains. High levels of serum immunoglobulin G1 antibody were induced by Freund's complete adjuvant vaccination in all cases. A relationship between vaccine efficacy, expulsion phenotype, and induced T-helper subset-associated cytokines (interleukin-5 and gamma interferon) was noted. It was concluded that effective vaccination against T. muris requires the induction of Th2 responses and that this can be achieved by both oral and parenteral administration of antigens.
机译：在高反应性BALB / c和低反应性C57BL / 10小鼠中，以Trichuris muris成虫蠕虫匀浆抗原作为佐剂的口服疫苗在高反应性BALB / c和低反应性C57BL / 10小鼠中均获得成功，因此对后续感染的防护水平较高，但在低水平时无效-应答者B10.BR小鼠。在弗氏完全佐剂中用抗原进行皮下接种可保护所有这些菌株，但对高反应性BALB / c最有效，而对B10.BR小鼠则最无效。口服疫苗仅在两个受保护的菌株中引起鼠毛衣原体特异性肠免疫球蛋白A应答。在所有情况下，弗氏完全佐剂疫苗都可诱导高水平的血清免疫球蛋白G1抗体。注意到疫苗效力，驱逐表型和诱导的T辅助亚群相关细胞因子（白介素5和γ干扰素）之间的关系。结论是针对鼠毛衣原体的有效疫苗接种需要诱导Th2反应，并且可以通过口服和肠胃外施用抗原来实现。

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