Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes.

J F Kokai-Kun; B A McClane

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Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes.

机译：当毒素被螯合在小或大复合物中时，产气荚膜梭菌肠毒素分子的一个或多个区域仍暴露在哺乳动物质膜的外表面上的证据。

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In studies performed to investigate the topology of Clostridium perfringens enterotoxin (CPE) when this toxin is associated with intestinal brush border membrane (BBMs), it was shown that radiolabeled CPE antibodies react more strongly against intact CPE-treated BBMs than against control BBMs. Immunoprecipitation studies then demonstrated that CPE antibodies are able to react with both small and large CPE-containing complexes while these complexes are still present in intact BBMs. Therefore, at least a portion of the CPE molecule appears to remain surface exposed in BBMs throughout the action of this toxin.

机译：在研究这种产气荚膜梭菌肠毒素（CPE）的拓扑结构时，该毒素与肠刷缘膜（BBMs）相关联，研究表明，放射性标记的CPE抗体对完整的CPE处理的BBM的反应比对对照的BBM的反应更强烈。免疫沉淀研究表明，CPE抗体能够与大大小小的含CPE的复合物反应，而这些复合物仍存在于完整的BBM中。因此，在该毒素的整个作用过程中，CPE分子的至少一部分似乎保持暴露在BBM中。

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《Infection and immunity》 |1996年第3期|共6页
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J F Kokai-Kun; B A McClane;
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1. Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes. [J] . J F Kokai-Kun, B A McClane Infection and immunity . 1996,第3期

机译：当毒素被螯合在小或大复合物中时，产气荚膜梭菌肠毒素分子的一个或多个区域仍暴露在哺乳动物质膜的外表面上的证据。
2. Preliminary evidence that Clostridium perfringens type A enterotoxin is present in a 160,000-Mr complex in mammalian membranes. [J] . A P Wnek, B A McClane Infection and immunity . 1989,第2期

机译：初步证据表明，产气荚膜梭菌肠毒素存在于哺乳动物膜中的160,000-Mr复合物中。
3. Preliminary evidence that Clostridium perfringens type A enterotoxin is present in a 160,000-Mr complex in mammalian membranes. [J] . A P Wnek, B A McClane Infection and immunity . 1989,第2期

机译：初步证据表明，产气荚膜梭菌肠毒素存在于哺乳动物膜中的160,000-Mr复合物中。
4. Evaluation of the Ability of Di-tri-octahedral Smectite to Adhere to Clostridium difficile Toxins and Clostridium perfringens Enterotoxin In Vitro [C] . J. S. Weese, N. M. Cote, R. V. G. deGannes Annual Convention of the American Association of Equine Practitioners . 2002

机译：评价Di-Tri-octaheDral蒙脱石粘附到梭菌腹菌毒素和梭菌梭菌中的能力
5. Studying lateral mobility of surface molecules on the plasma membrane using biophysical approaches. [D] . Chen, Yun. 2007

机译：使用生物物理方法研究质膜表面分子的横向迁移。
6. Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes. [O] . J F Kokai-Kun, B A McClane 1996

机译：当毒素被螯合成小或大复合物时产气荚膜梭菌肠毒素分子的一个或多个区域仍暴露在哺乳动物质膜的外表面上的证据。
7. Preliminary evidence that Clostridium perfringens type A enterotoxin is present in a 160,000-Mr complex in mammalian membranes [O] . A P Wnek, B A McClane 1989

机译：初步证据表明梭菌强度型肠毒素存在于哺乳动物膜中的160,000-mr复合物中存在
8. Detergent-Resistant Membrane Microdomains Facilitate Ib Oligomer Formation and Biological Activity of Clostridium perfringens Iota-Toxin [R] . Hale, M. L. , Marvaud, J. , Popoff, M. R. , 2004

机译：耐洗涤剂膜微区促进产气荚膜梭菌Iota-毒素的Ib低聚物形成和生物活性

Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes.

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