• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >The gamma/delta T-cell response to Plasmodium falciparum malaria in a population in which malaria is endemic.
【24h】

The gamma/delta T-cell response to Plasmodium falciparum malaria in a population in which malaria is endemic.

机译：在疟疾流行地区，对恶性疟原虫疟疾的γ/δT细胞反应。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Frequencies and absolute numbers of peripheral gamma/delta T cells have been reported to increase after episodes of Plasmodium falciparum malaria in adults with limited or no previous malaria exposure. In contrast, little is known about the gamma/delta T-cell response to malaria in children from areas where malaria is endemic, who bear the burden of malaria-related morbidity and mortality. We investigated the gamma/delta T-cell response in 19 Ghanaian children from an area of hyperendemic, seasonal malaria transmission. The children presented with cerebral malaria (n = 7), severe malarial anemia (n = 5), or uncomplicated malaria (n = 7) and were monitored from admission until 4 weeks later. We found no evidence of increased frequencies of gamma/delta T cells in any of the patient groups, whereas one adult expatriate studied in Ghana and three adults admitted to the hospital in Copenhagen, Denmark, all with uncomplicated, primary P. falciparum malaria, showed increased gamma/delta T-cell frequencies similar to those previously reported. All patients had lowered absolute numbers of peripheral gamma/delta T cells at admission, changing to increased numbers by days 7 to 14 and then returning to normal levels. The study raises questions regarding age and degree of previous exposure as determinants of malaria-induced gamma/delta T-cell responses.
机译：据报道，患有疟疾的人很少或以前没有接触疟疾，恶性疟原虫疟疾发作后，外周γ/δT细胞的频率和绝对数目增加。相比之下，对于疟疾流行地区儿童的γ/δT细胞对疟疾的反应知之甚少，这些儿童承担了与疟疾相关的发病率和死亡率的重担。我们调查了高流行，季节性疟疾传播地区的19名加纳儿童的γ/δT细胞反应。这些患儿患有脑型疟疾（n = 7），严重的疟疾贫血（n = 5）或单纯性疟疾（n = 7），并从入院到4周后接受监测。我们没有发现任何患者组中γ/δT细胞频率增加的证据，而在加纳研究的一名成年外籍人员和丹麦哥本哈根住院的三名成年患者均患有简单的原发性恶性疟原虫疟疾。 γ/δT细胞频率增加，类似于先前报道的频率。所有患者入院时外周γ/δT细胞的绝对数量均降低，到第7至14天时其数量增加，然后恢复正常水平。这项研究提出了有关年龄和以前接触程度的问题，这些因素是疟疾诱发的γ/δT细胞反应的决定因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号