Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection.

S A Rezende; V R Oliveira; A M Silva; J B Alves; A M Goes; L F Reis

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Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection.

机译：缺乏γ干扰素受体的小鼠对曼氏血吸虫感染的肉芽肿反应受损。

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The egg-induced granulomatous reaction in Schistosoma mansoni-infected individuals develops within the portal system of the liver and is the major pathological finding in schistosomiasis. We have infected mice lacking the gamma interferon (IFN-gamma) receptor with S. mansoni larvae and studied the development of hepatic granulomas in these mutant mice in comparison to that in control wild-type mice. In the absence of IFN-gamma activity, a dramatic reduction in the size and architecture of the granuloma was observed. Granulomas from mutant mice were smaller than those from the control group and showed a significant reduction in the number of infiltrating inflammatory cells. Moreover, they appear to prematurely progress to the chronic phase of the reaction at a time when the control group still has acute inflammation. Our data suggests a pivotal role for IFN-gamma in the early events of the granulomatous reaction in vivo.

机译：在曼氏血吸虫感染的个体中，鸡蛋引起的肉芽肿反应在肝脏的门脉系统内发展，是血吸虫病的主要病理发现。我们已经用曼氏链球菌幼虫感染了缺乏γ-干扰素（IFN-γ）受体的小鼠，并与对照野生型小鼠相比，研究了这些突变小鼠中肝肉芽肿的发展。在没有IFN-γ活性的情况下，观察到肉芽肿的大小和结构显着减小。来自突变小鼠的肉芽肿小于对照组的肉芽肿，并显示出浸润性炎症细胞数量的显着减少。而且，在对照组仍具有急性炎症时，它们似乎过早地发展到反应的慢性阶段。我们的数据表明，IFN-γ在体内肉芽肿反应的早期事件中起着关键作用。

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《Infection and immunity》 |1997年第8期|共5页
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S A Rezende; V R Oliveira; A M Silva; J B Alves; A M Goes; L F Reis;
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中图分类医学免疫学;
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1. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection. [J] . S A Rezende, V R Oliveira, A M Silva, Infection and immunity . 1997,第8期

机译：缺乏γ干扰素受体的小鼠对曼氏血吸虫感染的肉芽肿反应受损。
2. Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni. [J] . G Yap, A Cheever, P Caspar, Infection and immunity . 1997,第7期

机译：在慢性感染曼氏血吸虫的CD8 T细胞和γ干扰素缺陷型小鼠中，肝肉芽肿反应的下调下调。
3. Schistosoma mansoni egg-induced hepatic granulomas in mice deficient for the interferon-gamma receptor have altered populations of macrophages, lymphocytes and connective tissue cells. [J] . Oliveira VR, El-Cheikh MC, Aguiar AM, Microbes and infection . 2000,第15期

机译：曼氏血吸虫鸡蛋诱导的肝肉芽肿缺乏干扰素-γ受体，小鼠的巨噬细胞，淋巴细胞和结缔组织细胞数量发生了变化。
4. Identification of Somatostatin Receptors on Schistosoma Mansoni Stages [C] . S. Chatterjee, J. Op De Beeck, E. Van Marc International Congress of Parasitology . 2006

机译：血吸虫曼逊阶段生长抑素受体的鉴定
5. Mechanisms of CD4+ T cell apoptosis during murine Schistosoma mansoni infection. [D] . Lundy, Steven Karl. 2001

机译：曼氏血吸虫感染过程中CD4 + T细胞凋亡的机制。
6. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection. [O] . S A Rezende, V R Oliveira, A M Silva, 1997

机译：缺乏γ干扰素受体的小鼠对曼氏血吸虫感染的肉芽肿反应受损。
7. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection [O] . S A Rezende, V R Oliveira, A M Silva, 1997

机译：缺乏γ干扰素受体的小鼠对血吸虫曼逊感染有损伤的肉芽肿反应
8. Modulation of Cell-Mediated Immunity in Mice with Chronic Unisexual or Bisexual Schistosoma mansoni Cercarial Infection. (Reannouncement with New Availability Information). [R] . Diab, M., Kamal, K., Cavender, D., 1989

机译：调节细胞介导的免疫小鼠与慢性单性或双性恋曼氏血吸虫感染。（重新公布新的可用性信息）。

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Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection.

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