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首页> 外文期刊>Infection and immunity >Human Onchocerciasis and Tetanus Vaccination: Impact on the Postvaccination Antitetanus Antibody Response
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Human Onchocerciasis and Tetanus Vaccination: Impact on the Postvaccination Antitetanus Antibody Response

机译：人盘尾丝虫病和破伤风疫苗接种：对疫苗接种后抗破伤风抗体反应的影响

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To investigate whether helminth infections may affect the efficacy of vaccines by impairing the immune response to nonparasite vaccine antigens, we compared the antibody responses to tetanus toxoid (TT) after tetanus vaccination in 193 subjects with Onchocerca volvulus infection with 85 comparable noninfected controls. After vaccination, the proportions of subjects in each group attaining protective levels of antitetanus antibodies were similar (96.9% infected versus 97.6% noninfected). Postvaccination increases in antitetanus immunoglobulin G (IgG) and the predominant IgG isotype, IgG1, were equivalent in both groups, as were increases in specific IgG4 and IgE; however, significantly greater increases in specific IgG2 (P < 0.05) and IgG3 (P < 0.001) were observed in the noninfected group. Stratification of the O. volvulus-infected group into two groups representing light and heavy infections revealed a significantly impaired antitetanus IgG response in those with heavy infections compared to those with light infections (P < 0.01) or no infection (P < 0.05). The impact of concurrent intestinal helminth infections on the antitetanus response was also examined; an increased IgG4/IgE ratio was seen in those infected withStrongyloides stercoralis (P < 0.05) and when all helminth infections were combined as a single group (P < 0.05). These findings indicate that concurrent infection with O. volvulus does not prevent the development of a protective antitetanus response, although heavier O. volvulus infections are able to alter the magnitude of this response, and concurrent helminth infections (O. volvulusand intestinal helminths) may alter TT-specific antibody isotype responses.
机译：为了研究蠕虫感染是否会通过削弱对非寄生虫疫苗抗原的免疫反应来影响疫苗的功效，我们比较了破伤风疫苗接种后的193名 Onchocerca volvulus 感染对象中破伤风疫苗接种后对破伤风类毒素（TT）的抗体反应。 85个可比的未感染对照。接种疫苗后，每组达到抗破伤风抗体保护水平的受试者比例相似（感染率为96.9％，未感染率为97.6％）。两组疫苗接种后抗破伤风免疫球蛋白G（IgG）和主要IgG同种型IgG1的增加相等，特异性IgG4和IgE的增加也相同。但是，未感染组的特异性IgG2（ P <0.05）和IgG3（ P <0.001）明显增加。 O的分层。肠粘膜感染分为两组，分别代表轻度感染和重度感染，与轻度感染（ P <0.01）或无感染（ P <0.01 P <0.05）。还检查了并发肠蠕虫感染对抗破伤风反应的影响;感染 sterongyloides stercoralis （ P <0.05）的人和所有蠕虫感染合并为一个组（ P < / em> <0.05）。这些发现表明并发感染 O。肠螺虽然阻止了 O的增重，但却不能阻止抗破伤风保护性反应的发展。肠螺旋菌感染能够改变这种反应的强度，同时发生的蠕虫感染（肠弯曲菌和肠蠕虫）可能会改变TT特异性抗体同种型反应。

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