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The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice

机译:BALB / c小鼠中布鲁氏菌流产的致病力不需要铁载体2,3-二羟基苯甲酸

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2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (ΔentC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.
机译:2,3-二羟基苯甲酸(DHBA)是描述 Brucella 的唯一铁载体,以前的研究表明DHBA可能有助于这些生物在宿主巨噬细胞中的存活能力。利用强毒的流产布鲁氏菌 2308构建的等基因铁载体突变体(ΔentC),我们发现在培养的小鼠巨噬细胞中复制或建立DHBA并不需要和维持BALB / c小鼠模型的慢性感染。

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