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首页> 外文期刊>Infection and immunity >Induction of biologically active antibodies by a polyvalent synthetic vaccine constructed without carrier.
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Induction of biologically active antibodies by a polyvalent synthetic vaccine constructed without carrier.

机译：通过无载体构建的多价合成疫苗诱导生物活性抗体。

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Four synthetic peptides that copy fragments of two bacterial antigens (Streptococcus pyogenes M protein and diphtheria toxin), one viral antigen (hepatitis B surface antigen), and one parasitic antigen (circumsporozoite protein of Plasmodium knowlesi) were covalently bound within the same construct. This totally synthetic polyvalent administered to mice with Freund complete adjuvant or in saline with murabutide (an adjuvant-active muramyl peptide) elicited high levels of antibodies which, in certain cases, were shown to be biologically active. The results indicated that these antibodies recognized specifically the four peptides. None of the epitopes were immunodominant. It was also demonstrated that the association of several peptides enhanced their respective immunogenicities as compared with those of their homopolymers. Finally, this study shows that a totally synthetic vaccine administered in saline with a synthetic adjuvant can be immunogenic in the absence of a protein carrier.
机译：复制两种细菌抗原（化脓性链球菌M蛋白和白喉毒素），一种病毒抗原（乙型肝炎表面抗原）和一种寄生虫抗原（诺氏疟原虫的环子孢子蛋白）片段的四种合成肽共价结合在同一构建体中。对具有弗氏完全佐剂的小鼠或在含有murabutide（佐剂活性的鼠王肽）的盐水中给予小鼠的这种全合成多价键可产生高水平的抗体，在某些情况下，这些抗体被证明具有生物活性。结果表明这些抗体特异性识别四种肽。这些表位都不是免疫显性的。还证明了几种肽的结合与其均聚物相比增强了它们各自的免疫原性。最后，这项研究表明，在盐水中与合成佐剂一起使用的全合成疫苗在没有蛋白质载体的情况下可以具有免疫原性。

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