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首页> 外文期刊>Infection and immunity >Activation of mouse peritoneal macrophages in vitro or in vivo by recombinant murine gamma interferon inhibits the growth of Chlamydia trachomatis serovar L1.
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Activation of mouse peritoneal macrophages in vitro or in vivo by recombinant murine gamma interferon inhibits the growth of Chlamydia trachomatis serovar L1.

机译:重组鼠γ干扰素在体外或体内激活小鼠腹膜巨噬细胞可抑制沙眼衣原体血清型L1的生长。

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摘要

Peritoneal mouse macrophages activated in vitro with recombinant murine gamma interferon (10 ng/ml) or in vivo (10 micrograms per mouse) showed a significant decrease in the growth and yield of Chlamydia trachomatis. The restriction of the growth of C. trachomatis paralleled the expression of Iad on the macrophages. Mice that received macrophages activated in vitro with recombinant murine gamma interferon showed a significant decrease in the yield of chlamydial infection-forming units from their spleens and peritoneal fluids.
机译:体外用重组鼠γ干扰素(10 ng / ml)或体内(每只小鼠10微克)激活的腹膜小鼠巨噬细胞显示出沙眼衣原体的生长和产量显着降低。沙眼衣原体的生长限制与Iad在巨噬细胞上的表达平行。在体外接受重组鼠γ干扰素激活的巨噬细胞的小鼠显示,从脾脏和腹膜液中产生衣原体感染的单位的产量明显下降。

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