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首页> 外文期刊>Infection and immunity >A 25-kilodalton fraction from Mycobacterium tuberculosis that inhibits hexose monophosphate shunt activity, lysozyme release, and H2O2 production: reversal by gamma interferon.
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A 25-kilodalton fraction from Mycobacterium tuberculosis that inhibits hexose monophosphate shunt activity, lysozyme release, and H2O2 production: reversal by gamma interferon.

机译：结核分枝杆菌的25千达尔顿级分，可抑制己糖一磷酸分流活性，溶菌酶释放和H2O2产生：通过γ干扰素逆转。

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This study examined the effects of a 25-kilodalton (kDa) glycolipoprotein derived from Mycobacterium tuberculosis on phagocyte functions associated with antimicrobial activity. The 25-kDa fraction inhibited the ability of both polymorphonuclear cells and cultured monocytes to release lysozyme and produce hydrogen peroxide. In addition, the glycolipoprotein was capable of reducing hexose monophosphate shunt activity and interfered with the ability of polymorphonuclear cells to reduce Nitro Blue Tetrazolium. Inhibition of these antimicrobial systems was optimal at a 50-micrograms/ml concentration of the 25-kDa fraction. Gamma interferon, but not alpha interferon, partially reversed the inhibitory effect of the mycobacterial component in all of the systems assessed. These studies indicate important mechanisms in the understanding of the pathogenesis of tuberculosis and suggest that gamma interferon may have a therapeutic role in mycobacterial diseases.
机译：这项研究检查了源自结核分枝杆菌的25千达尔顿（kDa）糖脂蛋白对与抗菌活性相关的吞噬细胞功能的影响。 25 kDa的分数抑制了多形核细胞和培养的单核细胞释放溶菌酶并产生过氧化氢的能力。此外，糖脂蛋白能够降低己糖一磷酸分流活性，并干扰多形核细胞还原硝基蓝四唑的能力。在25-kDa级分的浓度为50微克/毫升时，对这些抗菌系统的抑制作用最佳。在所有评估的系统中，γ干扰素而非α干扰素可部分逆转分枝杆菌成分的抑制作用。这些研究表明了解结核病发病机制的重要机制，并表明γ干扰素可能在分枝杆菌疾病中具有治疗作用。

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