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首页> 外文期刊>Infection and immunity >Effects of neutrophils and in vitro oxidants on survival and phenotypic switching of Candida albicans WO-1.
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Effects of neutrophils and in vitro oxidants on survival and phenotypic switching of Candida albicans WO-1.

机译：中性粒细胞和体外氧化剂对白色念珠菌WO-1存活和表型转换的影响。

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The relationship to pathogenesis of the spontaneous phenotypic switching of Candida albicans is uncertain. Since neutrophils are critical in containment of disseminated candidiasis, we used these cells and some of their potentially microbicidal oxidative products to define effects on a C. albicans strain (WO-1) that exhibits characteristic, easily recognized switching between the white and opaque phenotypes. Blastoconidia of the opaque phenotypes were more susceptible than those of the white to killing by either intact neutrophils or cell-free oxidants, including reagent hydrogen peroxide or the myeloperoxidase-H2O2-Cl- system. Paralleling these findings, opaque blastoconidia were 2.8- to 3.6-fold more potent stimuli of neutrophil superoxide generation than were the white cells. In addition, both neutrophils and oxidants (reagent H2O2 or hypochlorous acid as well as the myeloperoxidase-H2O2-Cl- system) induced unidirectional increases in spontaneous rates of switching from white to opaque phenotypes. Differences in expression of C. albicans phenotypes therefore may determine relative susceptibility to neutrophil fungicidal mechanisms, and neutrophils themselves appear to be capable of selectively augmenting the switching process.
机译：白念珠菌自发表型转换与发病机制的关系尚不确定。由于中性粒细胞在控制弥散性念珠菌病中至关重要，因此我们使用这些细胞及其某些潜在的杀微生物氧化产物来确定对白色念珠菌菌株（WO-1）的影响，该菌株表现出特征性的，易于识别的白色和不透明表型之间的转换。不透明表型的芽孢杆菌比白色菌更容易被完整的嗜中性粒细胞或无细胞氧化剂（包括过氧化氢试剂或髓过氧化物酶-H2O2-Cl-系统）杀死。与这些发现相吻合的是，不透明的囊胚炎对中性粒细胞超氧化物生成的有效刺激是白细胞的2.8-3.6倍。此外，嗜中性粒细胞和氧化剂（试剂H2O2或次氯酸以及髓过氧化物酶-H2O2-Cl-系统）均导致自发性从白色表型转换为不透明表型的单向增加。因此，白色念珠菌表型表达的差异可能决定了对嗜中性粒细胞杀真菌机制的相对敏感性，并且嗜中性粒细胞本身似乎能够选择性地增加转换过程。

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