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首页> 外文期刊>Infection and immunity >Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum.
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Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum.

机译：恶性疟原虫的重组SERA蛋白在大猿猴中诱导的保护性免疫。

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摘要

We describe the vaccination of Panamanian monkeys (Aotus sp.) with two recombinant blood stage antigens that each contain a portion of the N-terminal region of the SERA (serine repeat antigen) protein of the malaria parasite Plasmodium falciparum. We immunized with either a 262-amino-acid SERA fragment (SERA I) that contains amino acids 24 to 285 of the 989-amino-acid protein or a 483-amino-acid SERA fragment (SERA N) that contains amino acids 24 to 506 as part of a fusion protein with human gamma interferon. The recombinant proteins were shown to stimulate protective immunity when administered with complete and incomplete Freund adjuvant. Four of six immunized monkeys challenged by intravenous inoculation with blood stage P. falciparum developed parasitemias that were reduced by at least 1,000-fold. Two of six immunized monkeys developed parasitemias which were comparable to the lowest parasitemia in one of four controls and were 50- to 1,000-fold lower than in the other three controls.
机译：我们描述了用两种重组血液阶段抗原接种巴拿马猴（Aotus sp。）的疫苗，每种抗原都包含疟疾寄生虫恶性疟原虫的SERA（丝氨酸重复抗原）蛋白的N端区域的一部分。我们用包含989个氨基酸蛋白的24至285位氨基酸的262个氨基酸的SERA片段（SERA I）或包含24个氨基酸的24至285个氨基酸的SERA片段（SERA N）进行了免疫。 506作为与人γ干扰素融合蛋白的一部分。当与完全和不完全的弗氏佐剂一起施用时，重组蛋白显示出刺激保护性免疫。静脉注射恶性疟原虫的六只免疫猴子中有四只发生了寄生虫病，寄生虫病减少了至少1,000倍。在六只经免疫接种的猴子中，有两只发生了寄生虫病，这与四个对照组之一中的最低寄生虫病相当，并且比其他三个对照组中的寄生虫病低50至1,000倍。

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